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Selected Module: B_9_4


Module Info

Module_Name B_9_4
Cell_Type B
Name B_9_4: CD4 TEM
Meta_Module B_7
Gene_Number 29

Genes:

AAK1, ANXA1, CD3D, CD3E, DENND2D, DNAJB1, FLT3LG, FYB1, FYN, GIMAP4, GIMAP7, IL32, IL7R, LAT, LCK, LEPROTL1, MGAT4A, NDFIP1, NOSIP, PIK3R1, RCAN3, RNF125, SEMA4D, SORL1, SPOCK2, SYNE2, TCF7, TOB1, TSPAN14


UMAP Visualizations


UMAP for B_9_4

UMAP for B_9_4


Word Cloud

Enriched TF

Wordcloud for B_9_4
TF p.adjust Genes
STTTCRNTTT 0.0261200492124706 FLT3LG/MGAT4A/SYNE2
YYCATTCAWW 0.0261200492124706 AAK1/FYN/TOB1
TTGCWCAAY 0.0452052181749493 DENND2D/TOB1
IRF1 0.0452052181749493 AAK1/FLT3LG/SYNE2
STAT6 0.0452052181749493 IL7R/LAT/LCK
ETS1 0.0452052181749493 FYN/GIMAP4/LCK
HEB 0.0452052181749493 AAK1/NOSIP/SPOCK2
ETS2 0.0470724566302483 FYN/IL7R/LAT


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
onek1k B_9_4 CD4 TEM CD4 TEM 10/23 65/6471 5.25444060548929e-15 5.25444060548929e-14 5.53099011104136e-15 CD3D/CD3E/DNAJB1/FLT3LG/IL32/IL7R/LEPROTL1/PIK3R1/SPOCK2/SYNE2 10
WikiPathways B_9_4 WP69 T cell receptor signaling 7/18 75/8836 7.04447695296938e-11 1.07076049685135e-08 7.711848453777e-09 CD3D/CD3E/FYB1/FYN/LAT/LCK/PIK3R1 7
MeSH_gene2pubmed B_9_4 D015375 Receptors, Interleukin-2 9/29 466/26076 1.25552859744711e-09 9.45240134575049e-07 6.04432943899441e-07 CD3D/CD3E/FLT3LG/FYB1/FYN/IL7R/LAT/LCK/PIK3R1 9
onek1k B_9_4 CD8 Naive CD8 Naive 8/23 106/6471 1.58900506588518e-09 5.71275634664667e-09 6.01342773331228e-10 CD3E/FLT3LG/IL7R/LEPROTL1/NOSIP/RCAN3/TCF7/TOB1 8
MeSH_gene2pubmed B_9_4 D017260 Receptor-CD3 Complex, Antigen, T-Cell 7/29 195/26076 1.59407919322828e-09 9.45240134575049e-07 6.04432943899441e-07 CD3D/CD3E/FYB1/FYN/LAT/LCK/PIK3R1 7
MeSH_gene2pubmed B_9_4 D017493 Leukocyte Common Antigens 9/29 481/26076 1.65637874049366e-09 9.45240134575049e-07 6.04432943899441e-07 CD3D/CD3E/FYB1/FYN/IL7R/LAT/LCK/PIK3R1/SEMA4D 9
onek1k B_9_4 CD8 TEM CD8 TEM 8/23 107/6471 1.713826903994e-09 5.71275634664667e-09 6.01342773331228e-10 CD3D/CD3E/FYN/IL32/LAT/LCK/PIK3R1/SYNE2 8
MeSH_gene2pubmed B_9_4 D019860 Lymphocyte Specific Protein Tyrosine Kinase p56(lck) 8/29 354/26076 3.56885139628277e-09 1.52746839760903e-06 9.76738276877391e-07 CD3D/CD3E/FYB1/FYN/LAT/LCK/PIK3R1/TOB1 8
MeSH_gene2pubmed B_9_4 D051746 ZAP-70 Protein-Tyrosine Kinase 7/29 234/26076 5.65154102339382e-09 1.93508764641004e-06 1.2373900345957e-06 CD3D/CD3E/FYB1/FYN/LAT/LCK/PIK3R1 7
reactome B_9_4 R-HSA-202433 Generation of second messenger molecules 5/23 34/11146 6.28658666758219e-09 1.4459149335439e-06 7.6100785975995e-07 CD3D/CD3E/FYB1/LAT/LCK 5