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Selected Module: B_9_4
Module Info
| Module_Name | B_9_4 |
| Cell_Type | B |
| Name | B_9_4: CD4 TEM |
| Meta_Module | B_7 |
| Gene_Number | 29 |
Genes:
AAK1, ANXA1, CD3D, CD3E, DENND2D, DNAJB1, FLT3LG, FYB1, FYN, GIMAP4, GIMAP7, IL32, IL7R, LAT, LCK, LEPROTL1, MGAT4A, NDFIP1, NOSIP, PIK3R1, RCAN3, RNF125, SEMA4D, SORL1, SPOCK2, SYNE2, TCF7, TOB1, TSPAN14
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| STAT4 | 0.00182775675931345 | AAK1/CD3D/LAT/LEPROTL1/NDFIP1 |
| AP4 | 0.00554051020280923 | LAT/LCK/SPOCK2/TCF7 |
| PEA3 | 0.00554051020280923 | CD3E/DENND2D/LCK/SORL1 |
| CETS1P54 | 0.00554051020280923 | CD3E/IL7R/NOSIP/TCF7 |
| AML | 0.00554051020280923 | IL7R/LCK/PIK3R1/TCF7 |
| RACCACAR | 0.00554051020280923 | IL7R/LCK/PIK3R1/TCF7 |
| HOXA4 | 0.00554051020280923 | NDFIP1/PIK3R1/SYNE2/TOB1 |
| ELK1 | 0.00554051020280923 | FYN/IL7R/LCK/TCF7 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| WikiPathways | B_9_4 | WP3937 | Microglia pathogen phagocytosis pathway | 2/18 | 40/8836 | 0.00292038207113268 | 0.0277436296757605 | 0.0199815615393289 | LAT/PIK3R1 | 2 |
| MeSH_gene2pubmed | B_9_4 | D013929 | Thromboxane B2 | 2/29 | 73/26076 | 0.00298858361297386 | 0.0197546530710859 | 0.0126320949298631 | LAT/LCK | 2 |
| MeSH_gene2pubmed | B_9_4 | D019606 | Phosphoamino Acids | 2/29 | 73/26076 | 0.00298858361297386 | 0.0197546530710859 | 0.0126320949298631 | FYN/LCK | 2 |
| GO | B_9_4 | GO:0002822 | regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 3/27 | 206/18986 | 0.0030387926619624 | 0.0430073572574956 | 0.0289662692339106 | ANXA1/IL7R/NDFIP1 | 3 |
| MeSH_gene2pubmed | B_9_4 | D017361 | Viral Nonstructural Proteins | 3/29 | 264/26076 | 0.00308585291861161 | 0.0203191546025503 | 0.0129930649204699 | FYN/LCK/PIK3R1 | 3 |
| GO | B_9_4 | GO:0019902 | phosphatase binding | 3/29 | 191/18737 | 0.00313460763352672 | 0.0355255531799695 | 0.0225471777148413 | LCK/PIK3R1/RCAN3 | 3 |
| GO | B_9_4 | GO:0038093 | Fc receptor signaling pathway | 2/27 | 59/18986 | 0.00316988661878681 | 0.0442481433499145 | 0.0298019621549964 | FYN/LCK | 2 |
| reactome | B_9_4 | R-HSA-8856828 | Clathrin-mediated endocytosis | 3/23 | 146/11146 | 0.00321755588069545 | 0.0172101826176733 | 0.00905799085140701 | AAK1/CD3D/IL7R | 3 |
| MeSH_gene2pubmed | B_9_4 | D043802 | GTP-Binding Protein alpha Subunits, Gq-G11 | 3/29 | 269/26076 | 0.00325309655438774 | 0.021338319161348 | 0.0136447687701684 | FYN/LCK/PIK3R1 | 3 |
| GO | B_9_4 | GO:0002707 | negative regulation of lymphocyte mediated immunity | 2/27 | 60/18986 | 0.00327632585732159 | 0.0451158925487932 | 0.0303864076667664 | IL7R/NDFIP1 | 2 |