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Selected Module: B_9_4
Module Info
| Module_Name | B_9_4 |
| Cell_Type | B |
| Name | B_9_4: CD4 TEM |
| Meta_Module | B_7 |
| Gene_Number | 29 |
Genes:
AAK1, ANXA1, CD3D, CD3E, DENND2D, DNAJB1, FLT3LG, FYB1, FYN, GIMAP4, GIMAP7, IL32, IL7R, LAT, LCK, LEPROTL1, MGAT4A, NDFIP1, NOSIP, PIK3R1, RCAN3, RNF125, SEMA4D, SORL1, SPOCK2, SYNE2, TCF7, TOB1, TSPAN14
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| STAT4 | 0.00182775675931345 | AAK1/CD3D/LAT/LEPROTL1/NDFIP1 |
| AP4 | 0.00554051020280923 | LAT/LCK/SPOCK2/TCF7 |
| PEA3 | 0.00554051020280923 | CD3E/DENND2D/LCK/SORL1 |
| CETS1P54 | 0.00554051020280923 | CD3E/IL7R/NOSIP/TCF7 |
| AML | 0.00554051020280923 | IL7R/LCK/PIK3R1/TCF7 |
| RACCACAR | 0.00554051020280923 | IL7R/LCK/PIK3R1/TCF7 |
| HOXA4 | 0.00554051020280923 | NDFIP1/PIK3R1/SYNE2/TOB1 |
| ELK1 | 0.00554051020280923 | FYN/IL7R/LCK/TCF7 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_9_4 | R-HSA-1257604 | PIP3 activates AKT signaling | 4/23 | 273/11146 | 0.00215874052191064 | 0.0134191978389039 | 0.00706273570468629 | FLT3LG/FYN/LCK/PIK3R1 | 4 |
| MeSH_gene2pubmed | B_9_4 | D018033 | Antibodies, Bispecific | 2/29 | 62/26076 | 0.00216679658958236 | 0.015592582083278 | 0.00997066242413254 | CD3D/CD3E | 2 |
| MeSH_gene2pubmed | B_9_4 | D000495 | Allosteric Site | 3/29 | 233/26076 | 0.00216766035970805 | 0.015592582083278 | 0.00997066242413254 | FYN/LCK/PIK3R1 | 3 |
| MeSH_gene2pubmed | B_9_4 | D019039 | Platelet Glycoprotein GPIIb-IIIa Complex | 3/29 | 233/26076 | 0.00216766035970805 | 0.015592582083278 | 0.00997066242413254 | FYN/LAT/PIK3R1 | 3 |
| MeSH_gene2pubmed | B_9_4 | D047392 | beta-Cyclodextrins | 3/29 | 233/26076 | 0.00216766035970805 | 0.015592582083278 | 0.00997066242413254 | FYN/LAT/LCK | 3 |
| MeSH_gene2pubmed | B_9_4 | D015689 | Oncogene Protein p21(ras) | 3/29 | 234/26076 | 0.00219417742058103 | 0.0157172876319445 | 0.0100504052737471 | FYN/LAT/PIK3R1 | 3 |
| GO | B_9_4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 2/29 | 45/18737 | 0.00219732400994954 | 0.029607303577436 | 0.0187910131064222 | FYN/LCK | 2 |
| GO | B_9_4 | GO:0046636 | negative regulation of alpha-beta T cell activation | 2/27 | 49/18986 | 0.00219786755665615 | 0.0339337430338275 | 0.0228550182925009 | ANXA1/NDFIP1 | 2 |
| MeSH_gene2pubmed | B_9_4 | D053631 | Interleukin Receptor Common gamma Subunit | 2/29 | 63/26076 | 0.00223629962367546 | 0.0158860786544912 | 0.0101583385395173 | FYN/IL7R | 2 |
| MeSH_gene2pubmed | B_9_4 | D054633 | Receptor-Like Protein Tyrosine Phosphatases, Class 5 | 2/29 | 63/26076 | 0.00223629962367546 | 0.0158860786544912 | 0.0101583385395173 | FYN/LCK | 2 |