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Selected Module: B_9_4
Module Info
| Module_Name | B_9_4 |
| Cell_Type | B |
| Name | B_9_4: CD4 TEM |
| Meta_Module | B_7 |
| Gene_Number | 29 |
Genes:
AAK1, ANXA1, CD3D, CD3E, DENND2D, DNAJB1, FLT3LG, FYB1, FYN, GIMAP4, GIMAP7, IL32, IL7R, LAT, LCK, LEPROTL1, MGAT4A, NDFIP1, NOSIP, PIK3R1, RCAN3, RNF125, SEMA4D, SORL1, SPOCK2, SYNE2, TCF7, TOB1, TSPAN14
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| STAT4 | 0.00182775675931345 | AAK1/CD3D/LAT/LEPROTL1/NDFIP1 |
| AP4 | 0.00554051020280923 | LAT/LCK/SPOCK2/TCF7 |
| PEA3 | 0.00554051020280923 | CD3E/DENND2D/LCK/SORL1 |
| CETS1P54 | 0.00554051020280923 | CD3E/IL7R/NOSIP/TCF7 |
| AML | 0.00554051020280923 | IL7R/LCK/PIK3R1/TCF7 |
| RACCACAR | 0.00554051020280923 | IL7R/LCK/PIK3R1/TCF7 |
| HOXA4 | 0.00554051020280923 | NDFIP1/PIK3R1/SYNE2/TOB1 |
| ELK1 | 0.00554051020280923 | FYN/IL7R/LCK/TCF7 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_9_4 | GO:0007034 | vacuolar transport | 3/27 | 173/18986 | 0.00185164410439242 | 0.0304326668125141 | 0.020496977182748 | LEPROTL1/NDFIP1/SORL1 | 3 |
| reactome | B_9_4 | R-HSA-76002 | Platelet activation, signaling and aggregation | 4/23 | 263/11146 | 0.00188346454548134 | 0.0123770527274488 | 0.00651423827760463 | FYN/LAT/LCK/PIK3R1 | 4 |
| MeSH_gene2pubmed | B_9_4 | D007073 | Immunoglobulin E | 4/29 | 482/26076 | 0.00189816420712551 | 0.0140677797515103 | 0.00899562896063126 | FLT3LG/FYN/LAT/TCF7 | 4 |
| MeSH_gene2pubmed | B_9_4 | D016572 | Cyclosporine | 4/29 | 484/26076 | 0.00192700858331964 | 0.0142199943734622 | 0.00909296246212536 | CD3E/FLT3LG/FYN/LAT | 4 |
| GO | B_9_4 | GO:0046633 | alpha-beta T cell proliferation | 2/27 | 46/18986 | 0.00193943498900474 | 0.0313695913300925 | 0.0211280135811377 | CD3E/NDFIP1 | 2 |
| reactome | B_9_4 | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 2/23 | 32/11146 | 0.00194570263850191 | 0.0124308779682066 | 0.00654256735168769 | FYN/PIK3R1 | 2 |
| MeSH_gene2pubmed | B_9_4 | D005231 | Fatty Acids, Unsaturated | 4/29 | 487/26076 | 0.0019708454781544 | 0.0144810620540787 | 0.00925990195292783 | FYN/LAT/NDFIP1/NOSIP | 4 |
| GO | B_9_4 | GO:2000516 | positive regulation of CD4-positive, alpha-beta T cell activation | 2/27 | 48/18986 | 0.00211000505340419 | 0.0335410843640087 | 0.022590555245425 | ANXA1/CD3E | 2 |
| GO | B_9_4 | GO:0042129 | regulation of T cell proliferation | 3/27 | 182/18986 | 0.00213951961105061 | 0.0335410843640087 | 0.022590555245425 | ANXA1/CD3E/NDFIP1 | 3 |
| MeSH_gene2pubmed | B_9_4 | D016246 | Lymphocytes, Tumor-Infiltrating | 3/29 | 232/26076 | 0.002141344437296 | 0.015592582083278 | 0.00997066242413254 | CD3E/FYN/LCK | 3 |