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Selected Module: B_9_4
Module Info
| Module_Name | B_9_4 |
| Cell_Type | B |
| Name | B_9_4: CD4 TEM |
| Meta_Module | B_7 |
| Gene_Number | 29 |
Genes:
AAK1, ANXA1, CD3D, CD3E, DENND2D, DNAJB1, FLT3LG, FYB1, FYN, GIMAP4, GIMAP7, IL32, IL7R, LAT, LCK, LEPROTL1, MGAT4A, NDFIP1, NOSIP, PIK3R1, RCAN3, RNF125, SEMA4D, SORL1, SPOCK2, SYNE2, TCF7, TOB1, TSPAN14
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| STAT4 | 0.00182775675931345 | AAK1/CD3D/LAT/LEPROTL1/NDFIP1 |
| AP4 | 0.00554051020280923 | LAT/LCK/SPOCK2/TCF7 |
| PEA3 | 0.00554051020280923 | CD3E/DENND2D/LCK/SORL1 |
| CETS1P54 | 0.00554051020280923 | CD3E/IL7R/NOSIP/TCF7 |
| AML | 0.00554051020280923 | IL7R/LCK/PIK3R1/TCF7 |
| RACCACAR | 0.00554051020280923 | IL7R/LCK/PIK3R1/TCF7 |
| HOXA4 | 0.00554051020280923 | NDFIP1/PIK3R1/SYNE2/TOB1 |
| ELK1 | 0.00554051020280923 | FYN/IL7R/LCK/TCF7 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_9_4 | GO:0032743 | positive regulation of interleukin-2 production | 2/27 | 35/18986 | 0.00112573571935376 | 0.0208568126912996 | 0.0140474581630364 | ANXA1/CD3E | 2 |
| GO | B_9_4 | GO:0038094 | Fc-gamma receptor signaling pathway | 2/27 | 35/18986 | 0.00112573571935376 | 0.0208568126912996 | 0.0140474581630364 | FYN/LCK | 2 |
| MeSH_gene2pubmed | B_9_4 | D054594 | Protein Tyrosine Phosphatase, Non-Receptor Type 12 | 2/29 | 45/26076 | 0.00114774457304632 | 0.0100766087643862 | 0.00644347830482146 | FYN/LCK | 2 |
| MeSH_gene2pubmed | B_9_4 | D011554 | Pseudopodia | 4/29 | 422/26076 | 0.00116573954436036 | 0.0101823780609435 | 0.00651111238525655 | FYB1/FYN/LAT/PIK3R1 | 4 |
| MeSH_gene2pubmed | B_9_4 | D006153 | Guanosine Diphosphate | 4/29 | 424/26076 | 0.00118625595113737 | 0.0103055388725726 | 0.00658986745417825 | FYN/GIMAP4/GIMAP7/PIK3R1 | 4 |
| reactome | B_9_4 | R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2/23 | 25/11146 | 0.00118721280922012 | 0.0091019648706876 | 0.00479050782667768 | FYN/PIK3R1 | 2 |
| GO | B_9_4 | GO:2000515 | negative regulation of CD4-positive, alpha-beta T cell activation | 2/27 | 36/18986 | 0.0011909114609655 | 0.0216703353343544 | 0.0145953810629607 | ANXA1/NDFIP1 | 2 |
| MeSH_gene2pubmed | B_9_4 | D018819 | Dipeptidyl Peptidase 4 | 3/29 | 189/26076 | 0.00119187891166436 | 0.0103055388725726 | 0.00658986745417825 | CD3D/CD3E/PIK3R1 | 3 |
| MeSH_gene2pubmed | B_9_4 | D018951 | Antigens, CD20 | 3/29 | 190/26076 | 0.00121009771572258 | 0.0104104888910405 | 0.00665697764798457 | CD3E/FYN/LCK | 3 |
| MeSH_gene2pubmed | B_9_4 | D051242 | Caveolin 1 | 4/29 | 430/26076 | 0.00124932936982248 | 0.0106069329259927 | 0.00678259360737361 | AAK1/FYN/LCK/NOSIP | 4 |