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Selected Module: B_9_4
Module Info
| Module_Name | B_9_4 |
| Cell_Type | B |
| Name | B_9_4: CD4 TEM |
| Meta_Module | B_7 |
| Gene_Number | 29 |
Genes:
AAK1, ANXA1, CD3D, CD3E, DENND2D, DNAJB1, FLT3LG, FYB1, FYN, GIMAP4, GIMAP7, IL32, IL7R, LAT, LCK, LEPROTL1, MGAT4A, NDFIP1, NOSIP, PIK3R1, RCAN3, RNF125, SEMA4D, SORL1, SPOCK2, SYNE2, TCF7, TOB1, TSPAN14
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| STAT4 | 0.00182775675931345 | AAK1/CD3D/LAT/LEPROTL1/NDFIP1 |
| AP4 | 0.00554051020280923 | LAT/LCK/SPOCK2/TCF7 |
| PEA3 | 0.00554051020280923 | CD3E/DENND2D/LCK/SORL1 |
| CETS1P54 | 0.00554051020280923 | CD3E/IL7R/NOSIP/TCF7 |
| AML | 0.00554051020280923 | IL7R/LCK/PIK3R1/TCF7 |
| RACCACAR | 0.00554051020280923 | IL7R/LCK/PIK3R1/TCF7 |
| HOXA4 | 0.00554051020280923 | NDFIP1/PIK3R1/SYNE2/TOB1 |
| ELK1 | 0.00554051020280923 | FYN/IL7R/LCK/TCF7 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| MeSH_gene2pubmed | B_9_4 | D053645 | Interleukin-2 Receptor alpha Subunit | 4/29 | 176/26076 | 4.17486771828372e-05 | 0.00083108994577927 | 0.00053143970954896 | ANXA1/FYB1/IL7R/LAT | 4 |
| GO | B_9_4 | GO:0031295 | T cell costimulation | 3/27 | 48/18986 | 4.25069285821068e-05 | 0.00354582425353197 | 0.00238817975652378 | CD3E/FYN/LCK | 3 |
| reactome | B_9_4 | R-HSA-202424 | Downstream TCR signaling | 4/23 | 98/11146 | 4.37688125024536e-05 | 0.00062917667972277 | 0.00033114562090672 | CD3D/CD3E/LCK/PIK3R1 | 4 |
| GO | B_9_4 | GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 5/27 | 284/18986 | 4.45605931561434e-05 | 0.00354582425353197 | 0.00238817975652378 | ANXA1/CD3E/FYN/IL7R/LCK | 5 |
| GO | B_9_4 | GO:0031294 | lymphocyte costimulation | 3/27 | 49/18986 | 4.52362269832342e-05 | 0.00354582425353197 | 0.00238817975652378 | CD3E/FYN/LCK | 3 |
| GO | B_9_4 | GO:0001772 | immunological synapse | 3/29 | 48/19960 | 4.56409616702696e-05 | 0.00520306963041073 | 0.00374736316871687 | CD3E/LAT/LCK | 3 |
| KEGG | B_9_4 | hsa04659 | Th17 cell differentiation | 4/17 | 109/8541 | 5.25614887062785e-05 | 0.00112131175906727 | 0.00083913955653883 | CD3D/CD3E/LAT/LCK | 4 |
| WikiPathways | B_9_4 | WP2203 | Thymic stromal lymphopoietin TSLP signaling | 3/18 | 37/8836 | 5.28229608417446e-05 | 0.00080290900479451 | 0.00057827241342541 | FYN/IL7R/LCK | 3 |
| WikiPathways | B_9_4 | WP49 | IL2 signaling | 3/18 | 37/8836 | 5.28229608417446e-05 | 0.00080290900479451 | 0.00057827241342541 | FYN/LCK/PIK3R1 | 3 |
| MeSH_gene2pubmed | B_9_4 | D015851 | Interleukin-7 | 4/29 | 187/26076 | 5.286584828377e-05 | 0.00104030266967603 | 0.00066522059546425 | FLT3LG/FYN/IL7R/PIK3R1 | 4 |