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Selected Module: B_8_2
Module Info
| Module_Name | B_8_2 |
| Cell_Type | B |
| Name | B_8_2: Mitochondrial Diseases |
| Meta_Module | B_3 |
| Gene_Number | 48 |
Genes:
ABRACL, ANAPC5, AP1S1, C1orf43, CBR1, COMMD4, DDX1, DDX49, DPM1, EIF4E2, FH, FUNDC2, IDH3A, MRPL14, MRPL28, MRPL3, MRPL32, MRPL58, MRPS18A, NABP2, NDUFA11, NDUFA8, NDUFAF3, NDUFB9, NDUFS3, NDUFS7, NDUFV1, PFDN6, POLR2E, PPP1R7, PSMA1, PSMB5, PSMC1, PSMD9, RNH1, RUVBL2, SKA2, SLC25A39, SLX9, SRPK1, STARD7, TALDO1, TIMM44, TPGS2, TPI1, USP14, VPS25, ZCRB1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| RLF | 4.65826687298153e-05 | ANAPC5/EIF4E2/MRPL3/MRPL58/NDUFS3/NDUFS7/PSMA1/SLX9 |
| ALKBH3 | 0.00163190543184927 | DDX1/EIF4E2/MRPL3/MRPL58/NDUFS7/SLX9/VPS25 |
| ZNF85 | 0.0251523044088028 | ABRACL/NABP2/NDUFS3/NDUFS7/VPS25 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_8_2 | R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5/41 | 72/11146 | 6.1108163041946e-06 | 0.00015328093376149 | 9.00205740640345e-05 | ANAPC5/PSMA1/PSMB5/PSMC1/PSMD9 | 5 |
| reactome | B_8_2 | R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 5/41 | 73/11146 | 6.54247888006371e-06 | 0.00015328093376149 | 9.00205740640345e-05 | ANAPC5/PSMA1/PSMB5/PSMC1/PSMD9 | 5 |
| reactome | B_8_2 | R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 5/41 | 73/11146 | 6.54247888006371e-06 | 0.00015328093376149 | 9.00205740640345e-05 | ANAPC5/PSMA1/PSMB5/PSMC1/PSMD9 | 5 |
| MeSH_gene2pubmed | B_8_2 | D012357 | RNA, Transfer, Lys | 4/48 | 66/26076 | 6.69671392270112e-06 | 0.00041763143190663 | 0.00035694446458799 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5/41 | 75/11146 | 7.47732924206436e-06 | 0.00016350426609314 | 9.60246492138792e-05 | ANAPC5/PSMA1/PSMB5/PSMC1/PSMD9 | 5 |
| reactome | B_8_2 | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5/41 | 76/11146 | 7.98235276348257e-06 | 0.00016363823165139 | 9.61033260340336e-05 | ANAPC5/PSMA1/PSMB5/PSMC1/PSMD9 | 5 |
| KEGG | B_8_2 | hsa05208 | Chemical carcinogenesis - reactive oxygen species | 7/29 | 227/8541 | 8.0930158220058e-06 | 5.21514526162079e-05 | 3.65975106078652e-05 | CBR1/NDUFA11/NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 7 |
| KEGG | B_8_2 | hsa04723 | Retrograde endocannabinoid signaling | 6/29 | 149/8541 | 8.69190876936798e-06 | 5.21514526162079e-05 | 3.65975106078652e-05 | NDUFA11/NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 6 |
| GO | B_8_2 | GO:0006164 | purine nucleotide biosynthetic process | 6/47 | 197/18986 | 8.71452094300879e-06 | 0.00018103714475153 | 0.00014943406031305 | NDUFA11/NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 6 |
| MeSH_gene2pubmed | B_8_2 | D003641 | Deamination | 4/48 | 71/26076 | 8.96745780029893e-06 | 0.0004815043573741 | 0.00041153587088748 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |