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Selected Module: B_8_2
Module Info
| Module_Name | B_8_2 |
| Cell_Type | B |
| Name | B_8_2: Mitochondrial Diseases |
| Meta_Module | B_3 |
| Gene_Number | 48 |
Genes:
ABRACL, ANAPC5, AP1S1, C1orf43, CBR1, COMMD4, DDX1, DDX49, DPM1, EIF4E2, FH, FUNDC2, IDH3A, MRPL14, MRPL28, MRPL3, MRPL32, MRPL58, MRPS18A, NABP2, NDUFA11, NDUFA8, NDUFAF3, NDUFB9, NDUFS3, NDUFS7, NDUFV1, PFDN6, POLR2E, PPP1R7, PSMA1, PSMB5, PSMC1, PSMD9, RNH1, RUVBL2, SKA2, SLC25A39, SLX9, SRPK1, STARD7, TALDO1, TIMM44, TPGS2, TPI1, USP14, VPS25, ZCRB1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| RLF | 4.65826687298153e-05 | ANAPC5/EIF4E2/MRPL3/MRPL58/NDUFS3/NDUFS7/PSMA1/SLX9 |
| ALKBH3 | 0.00163190543184927 | DDX1/EIF4E2/MRPL3/MRPL58/NDUFS7/SLX9/VPS25 |
| ZNF85 | 0.0251523044088028 | ABRACL/NABP2/NDUFS3/NDUFS7/VPS25 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_8_2 | GO:0009201 | ribonucleoside triphosphate biosynthetic process | 6/47 | 116/18986 | 3.99723605953405e-07 | 1.83872858738566e-05 | 1.51774752636443e-05 | NDUFA11/NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 6 |
| MeSH_gene2pubmed | B_8_2 | D042967 | Electron Transport Complex I | 6/48 | 163/26076 | 5.37221399956222e-07 | 6.14223133949948e-05 | 5.24968982062484e-05 | NDUFA11/NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 6 |
| WikiPathways | B_8_2 | WP111 | Electron transport chain OXPHOS system in mitochondria | 6/27 | 105/8836 | 5.89542532887215e-07 | 1.13407272456833e-05 | 8.03075422182356e-06 | NDUFA11/NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 6 |
| GO | B_8_2 | GO:0009142 | nucleoside triphosphate biosynthetic process | 6/47 | 124/18986 | 5.92701768398908e-07 | 2.54466625899264e-05 | 2.10045188099262e-05 | NDUFA11/NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 6 |
| WikiPathways | B_8_2 | WP4324 | Mitochondrial complex I assembly model OXPHOS system | 5/27 | 56/8836 | 6.18585122491814e-07 | 1.13407272456833e-05 | 8.03075422182356e-06 | NDUFA8/NDUFAF3/NDUFB9/NDUFS3/NDUFV1 | 5 |
| GO | B_8_2 | GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 5/46 | 68/18737 | 6.62174464075635e-07 | 2.26794753945905e-05 | 1.58573358502323e-05 | NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 5 |
| reactome | B_8_2 | R-HSA-5368286 | Mitochondrial translation initiation | 6/41 | 87/11146 | 6.86119403248687e-07 | 4.50094328531138e-05 | 2.64336527988441e-05 | MRPL14/MRPL28/MRPL3/MRPL32/MRPL58/MRPS18A | 6 |
| reactome | B_8_2 | R-HSA-5389840 | Mitochondrial translation elongation | 6/41 | 87/11146 | 6.86119403248687e-07 | 4.50094328531138e-05 | 2.64336527988441e-05 | MRPL14/MRPL28/MRPL3/MRPL32/MRPL58/MRPS18A | 6 |
| reactome | B_8_2 | R-HSA-5419276 | Mitochondrial translation termination | 6/41 | 87/11146 | 6.86119403248687e-07 | 4.50094328531138e-05 | 2.64336527988441e-05 | MRPL14/MRPL28/MRPL3/MRPL32/MRPL58/MRPS18A | 6 |
| GO | B_8_2 | GO:0032543 | mitochondrial translation | 6/47 | 131/18986 | 8.18815764798071e-07 | 3.29573345331224e-05 | 2.72040763962517e-05 | MRPL14/MRPL28/MRPL3/MRPL32/MRPL58/MRPS18A | 6 |