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Selected Module: B_8_2
Module Info
| Module_Name | B_8_2 |
| Cell_Type | B |
| Name | B_8_2: Mitochondrial Diseases |
| Meta_Module | B_3 |
| Gene_Number | 48 |
Genes:
ABRACL, ANAPC5, AP1S1, C1orf43, CBR1, COMMD4, DDX1, DDX49, DPM1, EIF4E2, FH, FUNDC2, IDH3A, MRPL14, MRPL28, MRPL3, MRPL32, MRPL58, MRPS18A, NABP2, NDUFA11, NDUFA8, NDUFAF3, NDUFB9, NDUFS3, NDUFS7, NDUFV1, PFDN6, POLR2E, PPP1R7, PSMA1, PSMB5, PSMC1, PSMD9, RNH1, RUVBL2, SKA2, SLC25A39, SLX9, SRPK1, STARD7, TALDO1, TIMM44, TPGS2, TPI1, USP14, VPS25, ZCRB1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| RLF | 4.65826687298153e-05 | ANAPC5/EIF4E2/MRPL3/MRPL58/NDUFS3/NDUFS7/PSMA1/SLX9 |
| ALKBH3 | 0.00163190543184927 | DDX1/EIF4E2/MRPL3/MRPL58/NDUFS7/SLX9/VPS25 |
| ZNF85 | 0.0251523044088028 | ABRACL/NABP2/NDUFS3/NDUFS7/VPS25 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_8_2 | GO:0005838 | proteasome regulatory particle | 2/47 | 22/19960 | 0.0012165250472143 | 0.00784658655453225 | 0.00557040416356023 | PSMC1/PSMD9 | 2 |
| reactome | B_8_2 | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4/41 | 129/11146 | 0.00124497858951435 | 0.0037810460866732 | 0.00222057584679459 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-69206 | G1/S Transition | 4/41 | 131/11146 | 0.00131796530236443 | 0.00396598733188561 | 0.00232919024947069 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| KEGG | B_8_2 | hsa05017 | Spinocerebellar ataxia | 4/29 | 144/8541 | 0.00132613961144378 | 0.00447572118862276 | 0.00314085697447211 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| WikiPathways | B_8_2 | WP78 | TCA cycle aka Krebs or citric acid cycle | 2/27 | 18/8836 | 0.0013349318944547 | 0.00815791713277873 | 0.00577689825670456 | FH/IDH3A | 2 |
| GO | B_8_2 | GO:0070199 | establishment of protein localization to chromosome | 2/47 | 22/18986 | 0.00134247860342479 | 0.0192123604579015 | 0.0158585191749596 | NABP2/RUVBL2 | 2 |
| MeSH_gene2pubmed | B_8_2 | D044843 | SKP Cullin F-Box Protein Ligases | 4/48 | 261/26076 | 0.00135047200825543 | 0.0205871955036272 | 0.0175956235929421 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4/41 | 134/11146 | 0.00143299378531594 | 0.00427292692348752 | 0.0025094532317016 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| MeSH_gene2pubmed | B_8_2 | D019562 | Viral Load | 4/48 | 269/26076 | 0.00150859264434626 | 0.0224977076961203 | 0.0192285149405233 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| GO | B_8_2 | GO:0022624 | proteasome accessory complex | 2/47 | 25/19960 | 0.00157281143793016 | 0.00966155597585669 | 0.0068588769473646 | PSMC1/PSMD9 | 2 |