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Selected Module: B_8_2
Module Info
| Module_Name | B_8_2 |
| Cell_Type | B |
| Name | B_8_2: Mitochondrial Diseases |
| Meta_Module | B_3 |
| Gene_Number | 48 |
Genes:
ABRACL, ANAPC5, AP1S1, C1orf43, CBR1, COMMD4, DDX1, DDX49, DPM1, EIF4E2, FH, FUNDC2, IDH3A, MRPL14, MRPL28, MRPL3, MRPL32, MRPL58, MRPS18A, NABP2, NDUFA11, NDUFA8, NDUFAF3, NDUFB9, NDUFS3, NDUFS7, NDUFV1, PFDN6, POLR2E, PPP1R7, PSMA1, PSMB5, PSMC1, PSMD9, RNH1, RUVBL2, SKA2, SLC25A39, SLX9, SRPK1, STARD7, TALDO1, TIMM44, TPGS2, TPI1, USP14, VPS25, ZCRB1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| RLF | 4.65826687298153e-05 | ANAPC5/EIF4E2/MRPL3/MRPL58/NDUFS3/NDUFS7/PSMA1/SLX9 |
| ALKBH3 | 0.00163190543184927 | DDX1/EIF4E2/MRPL3/MRPL58/NDUFS7/SLX9/VPS25 |
| ZNF85 | 0.0251523044088028 | ABRACL/NABP2/NDUFS3/NDUFS7/VPS25 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_8_2 | GO:0022853 | active monoatomic ion transmembrane transporter activity | 5/46 | 287/18737 | 0.00066770969048485 | 0.00914762275964248 | 0.00639595598253911 | NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 5 |
| reactome | B_8_2 | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4/41 | 112/11146 | 0.00073467039790966 | 0.00238586030212249 | 0.00140119523520031 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-5610787 | Hedgehog 'off' state | 4/41 | 113/11146 | 0.00075961647632327 | 0.00244268827680426 | 0.00143456981596656 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| MeSH_gene2pubmed | B_8_2 | D010453 | Peptide Synthases | 4/48 | 225/26076 | 0.00077987662211092 | 0.0133748840692023 | 0.0114313494346259 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| GO | B_8_2 | GO:0007005 | mitochondrion organization | 6/47 | 452/18986 | 0.00082732111061946 | 0.0121089726190667 | 0.00999514738906289 | NDUFA11/NDUFA8/NDUFAF3/NDUFB9/NDUFS3/NDUFS7 | 6 |
| GO | B_8_2 | GO:0051536 | iron-sulfur cluster binding | 3/46 | 76/18737 | 0.00085875522638461 | 0.0101841205436819 | 0.00712066822493316 | NDUFS7/NDUFV1/SLC25A39 | 3 |
| MeSH_gene2pubmed | B_8_2 | D003588 | Cytopathogenic Effect, Viral | 4/48 | 233/26076 | 0.00088808774300983 | 0.0148592241879207 | 0.0126999967357248 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| GO | B_8_2 | GO:0051540 | metal cluster binding | 3/46 | 77/18737 | 0.00089203975565096 | 0.0101841205436819 | 0.00712066822493316 | NDUFS7/NDUFV1/SLC25A39 | 3 |
| reactome | B_8_2 | R-HSA-202403 | TCR signaling | 4/41 | 120/11146 | 0.00095132536066069 | 0.00300033382977603 | 0.00176207025304562 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4/41 | 120/11146 | 0.00095132536066069 | 0.00300033382977603 | 0.00176207025304562 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |