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Selected Module: B_8_2
Module Info
| Module_Name | B_8_2 |
| Cell_Type | B |
| Name | B_8_2: Mitochondrial Diseases |
| Meta_Module | B_3 |
| Gene_Number | 48 |
Genes:
ABRACL, ANAPC5, AP1S1, C1orf43, CBR1, COMMD4, DDX1, DDX49, DPM1, EIF4E2, FH, FUNDC2, IDH3A, MRPL14, MRPL28, MRPL3, MRPL32, MRPL58, MRPS18A, NABP2, NDUFA11, NDUFA8, NDUFAF3, NDUFB9, NDUFS3, NDUFS7, NDUFV1, PFDN6, POLR2E, PPP1R7, PSMA1, PSMB5, PSMC1, PSMD9, RNH1, RUVBL2, SKA2, SLC25A39, SLX9, SRPK1, STARD7, TALDO1, TIMM44, TPGS2, TPI1, USP14, VPS25, ZCRB1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| RLF | 4.65826687298153e-05 | ANAPC5/EIF4E2/MRPL3/MRPL58/NDUFS3/NDUFS7/PSMA1/SLX9 |
| ALKBH3 | 0.00163190543184927 | DDX1/EIF4E2/MRPL3/MRPL58/NDUFS7/SLX9/VPS25 |
| ZNF85 | 0.0251523044088028 | ABRACL/NABP2/NDUFS3/NDUFS7/VPS25 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_8_2 | R-HSA-2871837 | FCERI mediated NF-kB activation | 4/41 | 82/11146 | 0.0002240145684626 | 0.00093893509500614 | 0.0005514285057321 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-9013694 | Signaling by NOTCH4 | 4/41 | 82/11146 | 0.0002240145684626 | 0.00093893509500614 | 0.0005514285057321 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-446652 | Interleukin-1 family signaling | 5/41 | 153/11146 | 0.0002296289955634 | 0.00093893509500614 | 0.0005514285057321 | PSMA1/PSMB5/PSMC1/PSMD9/USP14 | 5 |
| reactome | B_8_2 | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4/41 | 83/11146 | 0.00023473377375153 | 0.00093893509500614 | 0.0005514285057321 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4/41 | 83/11146 | 0.00023473377375153 | 0.00093893509500614 | 0.0005514285057321 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-69202 | Cyclin E associated events during G1/S transition | 4/41 | 83/11146 | 0.00023473377375153 | 0.00093893509500614 | 0.0005514285057321 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| MeSH_gene2pubmed | B_8_2 | D009955 | Ornithine Decarboxylase | 4/48 | 165/26076 | 0.00024209919998102 | 0.00553600170623285 | 0.00473155278559414 | DDX1/PSMA1/PSMB5/PSMD9 | 4 |
| KEGG | B_8_2 | hsa03010 | Ribosome | 5/29 | 172/8541 | 0.00025073894652392 | 0.00096713593659229 | 0.00067869188532792 | MRPL14/MRPL28/MRPL3/MRPL32/MRPS18A | 5 |
| reactome | B_8_2 | R-HSA-5632684 | Hedgehog 'on' state | 4/41 | 85/11146 | 0.00025727380678941 | 0.0010045929598444 | 0.0005899888050434 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4/41 | 85/11146 | 0.00025727380678941 | 0.0010045929598444 | 0.0005899888050434 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |