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Selected Module: B_8_2
Module Info
| Module_Name | B_8_2 |
| Cell_Type | B |
| Name | B_8_2: Mitochondrial Diseases |
| Meta_Module | B_3 |
| Gene_Number | 48 |
Genes:
ABRACL, ANAPC5, AP1S1, C1orf43, CBR1, COMMD4, DDX1, DDX49, DPM1, EIF4E2, FH, FUNDC2, IDH3A, MRPL14, MRPL28, MRPL3, MRPL32, MRPL58, MRPS18A, NABP2, NDUFA11, NDUFA8, NDUFAF3, NDUFB9, NDUFS3, NDUFS7, NDUFV1, PFDN6, POLR2E, PPP1R7, PSMA1, PSMB5, PSMC1, PSMD9, RNH1, RUVBL2, SKA2, SLC25A39, SLX9, SRPK1, STARD7, TALDO1, TIMM44, TPGS2, TPI1, USP14, VPS25, ZCRB1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| RLF | 4.65826687298153e-05 | ANAPC5/EIF4E2/MRPL3/MRPL58/NDUFS3/NDUFS7/PSMA1/SLX9 |
| ALKBH3 | 0.00163190543184927 | DDX1/EIF4E2/MRPL3/MRPL58/NDUFS7/SLX9/VPS25 |
| ZNF85 | 0.0251523044088028 | ABRACL/NABP2/NDUFS3/NDUFS7/VPS25 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| MeSH_gene2pubmed | B_8_2 | D002239 | Carbohydrate Metabolism, Inborn Errors | 3/48 | 47/26076 | 8.96642684887694e-05 | 0.00250190184481088 | 0.00213834483283667 | DPM1/FH/TALDO1 | 3 |
| reactome | B_8_2 | R-HSA-5358346 | Hedgehog ligand biogenesis | 4/41 | 65/11146 | 9.07135463105749e-05 | 0.00051786417988488 | 0.00030413717881557 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| MeSH_gene2pubmed | B_8_2 | D003562 | Cytidine | 4/48 | 128/26076 | 9.1177180933341e-05 | 0.00250190184481088 | 0.00213834483283667 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| MeSH_gene2pubmed | B_8_2 | D012192 | Retroviridae Infections | 4/48 | 128/26076 | 9.1177180933341e-05 | 0.00250190184481088 | 0.00213834483283667 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5/41 | 126/11146 | 9.22153382178931e-05 | 0.00051786417988488 | 0.00030413717881557 | PSMA1/PSMB5/PSMC1/PSMD9/TALDO1 | 5 |
| reactome | B_8_2 | R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4/41 | 66/11146 | 9.63101066249324e-05 | 0.00051786417988488 | 0.00030413717881557 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4/41 | 66/11146 | 9.63101066249324e-05 | 0.00051786417988488 | 0.00030413717881557 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4/41 | 66/11146 | 9.63101066249324e-05 | 0.00051786417988488 | 0.00030413717881557 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-1169091 | Activation of NF-kappaB in B cells | 4/41 | 67/11146 | 0.00010215359099029 | 0.00054042544910993 | 0.00031738721818715 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-162909 | Host Interactions of HIV factors | 5/41 | 130/11146 | 0.00010692309302448 | 0.00054624897317429 | 0.00032080732378336 | AP1S1/PSMA1/PSMB5/PSMC1/PSMD9 | 5 |