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Selected Module: B_8_2
Module Info
| Module_Name | B_8_2 |
| Cell_Type | B |
| Name | B_8_2: Mitochondrial Diseases |
| Meta_Module | B_3 |
| Gene_Number | 48 |
Genes:
ABRACL, ANAPC5, AP1S1, C1orf43, CBR1, COMMD4, DDX1, DDX49, DPM1, EIF4E2, FH, FUNDC2, IDH3A, MRPL14, MRPL28, MRPL3, MRPL32, MRPL58, MRPS18A, NABP2, NDUFA11, NDUFA8, NDUFAF3, NDUFB9, NDUFS3, NDUFS7, NDUFV1, PFDN6, POLR2E, PPP1R7, PSMA1, PSMB5, PSMC1, PSMD9, RNH1, RUVBL2, SKA2, SLC25A39, SLX9, SRPK1, STARD7, TALDO1, TIMM44, TPGS2, TPI1, USP14, VPS25, ZCRB1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| RLF | 4.65826687298153e-05 | ANAPC5/EIF4E2/MRPL3/MRPL58/NDUFS3/NDUFS7/PSMA1/SLX9 |
| ALKBH3 | 0.00163190543184927 | DDX1/EIF4E2/MRPL3/MRPL58/NDUFS7/SLX9/VPS25 |
| ZNF85 | 0.0251523044088028 | ABRACL/NABP2/NDUFS3/NDUFS7/VPS25 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_8_2 | R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4/41 | 60/11146 | 6.62088513046046e-05 | 0.00040974534392283 | 0.00024063991636033 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4/41 | 60/11146 | 6.62088513046046e-05 | 0.00040974534392283 | 0.00024063991636033 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4/41 | 60/11146 | 6.62088513046046e-05 | 0.00040974534392283 | 0.00024063991636033 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| GO | B_8_2 | GO:0003735 | structural constituent of ribosome | 5/46 | 175/18737 | 6.74766606074951e-05 | 0.00132061464331812 | 0.00092336482936572 | MRPL14/MRPL28/MRPL3/MRPL32/MRPS18A | 5 |
| MeSH_gene2pubmed | B_8_2 | D009700 | Nucleoside Deaminases | 4/48 | 119/26076 | 6.86956411673219e-05 | 0.00224405761146585 | 0.00191796852782949 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4/41 | 61/11146 | 7.06672616304751e-05 | 0.00042923818175547 | 0.00025208789236602 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-69239 | Synthesis of DNA | 5/41 | 120/11146 | 7.31329288806864e-05 | 0.00043613819405209 | 0.0002561402102424 | ANAPC5/PSMA1/PSMB5/PSMC1/PSMD9 | 5 |
| MeSH_gene2pubmed | B_8_2 | D008661 | Metabolism, Inborn Errors | 5/48 | 243/26076 | 8.32829769912584e-05 | 0.00250190184481088 | 0.00213834483283667 | FH/NDUFA8/NDUFS7/NDUFV1/TALDO1 | 5 |
| reactome | B_8_2 | R-HSA-4608870 | Asymmetric localization of PCP proteins | 4/41 | 64/11146 | 8.53574043604863e-05 | 0.00049995051125427 | 0.00029361663530016 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| GO | B_8_2 | GO:0015078 | proton transmembrane transporter activity | 5/46 | 185/18737 | 8.77546086860787e-05 | 0.0015027976737491 | 0.00105074597242542 | NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 5 |