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Selected Module: B_8_2
Module Info
| Module_Name | B_8_2 |
| Cell_Type | B |
| Name | B_8_2: Mitochondrial Diseases |
| Meta_Module | B_3 |
| Gene_Number | 48 |
Genes:
ABRACL, ANAPC5, AP1S1, C1orf43, CBR1, COMMD4, DDX1, DDX49, DPM1, EIF4E2, FH, FUNDC2, IDH3A, MRPL14, MRPL28, MRPL3, MRPL32, MRPL58, MRPS18A, NABP2, NDUFA11, NDUFA8, NDUFAF3, NDUFB9, NDUFS3, NDUFS7, NDUFV1, PFDN6, POLR2E, PPP1R7, PSMA1, PSMB5, PSMC1, PSMD9, RNH1, RUVBL2, SKA2, SLC25A39, SLX9, SRPK1, STARD7, TALDO1, TIMM44, TPGS2, TPI1, USP14, VPS25, ZCRB1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| RLF | 4.65826687298153e-05 | ANAPC5/EIF4E2/MRPL3/MRPL58/NDUFS3/NDUFS7/PSMA1/SLX9 |
| ALKBH3 | 0.00163190543184927 | DDX1/EIF4E2/MRPL3/MRPL58/NDUFS7/SLX9/VPS25 |
| ZNF85 | 0.0251523044088028 | ABRACL/NABP2/NDUFS3/NDUFS7/VPS25 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_8_2 | R-HSA-4641258 | Degradation of DVL | 4/41 | 57/11146 | 5.40614725784679e-05 | 0.00040974534392283 | 0.00024063991636033 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-69541 | Stabilization of p53 | 4/41 | 57/11146 | 5.40614725784679e-05 | 0.00040974534392283 | 0.00024063991636033 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-9020702 | Interleukin-1 signaling | 5/41 | 115/11146 | 5.96944173603165e-05 | 0.00040974534392283 | 0.00024063991636033 | PSMA1/PSMB5/PSMC1/PSMD9/USP14 | 5 |
| MeSH_gene2pubmed | B_8_2 | D004579 | Electron Transport | 5/48 | 228/26076 | 6.16525344448805e-05 | 0.0021146819314594 | 0.00180739272030518 | FH/NDUFA8/NDUFB9/NDUFS3/NDUFV1 | 5 |
| reactome | B_8_2 | R-HSA-351202 | Metabolism of polyamines | 4/41 | 59/11146 | 6.19591780283832e-05 | 0.00040974534392283 | 0.00024063991636033 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4/41 | 59/11146 | 6.19591780283832e-05 | 0.00040974534392283 | 0.00024063991636033 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4/41 | 59/11146 | 6.19591780283832e-05 | 0.00040974534392283 | 0.00024063991636033 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-2467813 | Separation of Sister Chromatids | 6/41 | 190/11146 | 6.20519032530712e-05 | 0.00040974534392283 | 0.00024063991636033 | ANAPC5/PSMA1/PSMB5/PSMC1/PSMD9/SKA2 | 6 |
| reactome | B_8_2 | R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4/41 | 60/11146 | 6.62088513046046e-05 | 0.00040974534392283 | 0.00024063991636033 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4/41 | 60/11146 | 6.62088513046046e-05 | 0.00040974534392283 | 0.00024063991636033 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |