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Selected Module: B_8_2
Module Info
| Module_Name | B_8_2 |
| Cell_Type | B |
| Name | B_8_2: Mitochondrial Diseases |
| Meta_Module | B_3 |
| Gene_Number | 48 |
Genes:
ABRACL, ANAPC5, AP1S1, C1orf43, CBR1, COMMD4, DDX1, DDX49, DPM1, EIF4E2, FH, FUNDC2, IDH3A, MRPL14, MRPL28, MRPL3, MRPL32, MRPL58, MRPS18A, NABP2, NDUFA11, NDUFA8, NDUFAF3, NDUFB9, NDUFS3, NDUFS7, NDUFV1, PFDN6, POLR2E, PPP1R7, PSMA1, PSMB5, PSMC1, PSMD9, RNH1, RUVBL2, SKA2, SLC25A39, SLX9, SRPK1, STARD7, TALDO1, TIMM44, TPGS2, TPI1, USP14, VPS25, ZCRB1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| RLF | 4.65826687298153e-05 | ANAPC5/EIF4E2/MRPL3/MRPL58/NDUFS3/NDUFS7/PSMA1/SLX9 |
| ALKBH3 | 0.00163190543184927 | DDX1/EIF4E2/MRPL3/MRPL58/NDUFS7/SLX9/VPS25 |
| ZNF85 | 0.0251523044088028 | ABRACL/NABP2/NDUFS3/NDUFS7/VPS25 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_8_2 | R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4/41 | 55/11146 | 4.69256365140158e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-4641257 | Degradation of AXIN | 4/41 | 55/11146 | 4.69256365140158e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 4/41 | 55/11146 | 4.69256365140158e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4/41 | 55/11146 | 4.69256365140158e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-9824272 | Somitogenesis | 4/41 | 55/11146 | 4.69256365140158e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| MeSH_gene2pubmed | B_8_2 | D000140 | Acidosis, Lactic | 3/48 | 38/26076 | 4.7194422839728e-05 | 0.00170396705621334 | 0.00145635975189631 | NDUFA8/NDUFS7/NDUFV1 | 3 |
| reactome | B_8_2 | R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4/41 | 56/11146 | 5.04013125626717e-05 | 0.00040321050050137 | 0.00023680205902359 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-5362768 | Hh mutants are degraded by ERAD | 4/41 | 56/11146 | 5.04013125626717e-05 | 0.00040321050050137 | 0.00023680205902359 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| GO | B_8_2 | GO:0015399 | primary active transmembrane transporter activity | 5/46 | 166/18737 | 5.25121206136532e-05 | 0.00119902675401175 | 0.0008383513992706 | NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 5 |
| KEGG | B_8_2 | hsa05415 | Diabetic cardiomyopathy | 6/29 | 205/8541 | 5.32090065990296e-05 | 0.00022102202741135 | 0.00015510317713077 | NDUFA11/NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 6 |