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Selected Module: B_8_2
Module Info
| Module_Name | B_8_2 |
| Cell_Type | B |
| Name | B_8_2: Mitochondrial Diseases |
| Meta_Module | B_3 |
| Gene_Number | 48 |
Genes:
ABRACL, ANAPC5, AP1S1, C1orf43, CBR1, COMMD4, DDX1, DDX49, DPM1, EIF4E2, FH, FUNDC2, IDH3A, MRPL14, MRPL28, MRPL3, MRPL32, MRPL58, MRPS18A, NABP2, NDUFA11, NDUFA8, NDUFAF3, NDUFB9, NDUFS3, NDUFS7, NDUFV1, PFDN6, POLR2E, PPP1R7, PSMA1, PSMB5, PSMC1, PSMD9, RNH1, RUVBL2, SKA2, SLC25A39, SLX9, SRPK1, STARD7, TALDO1, TIMM44, TPGS2, TPI1, USP14, VPS25, ZCRB1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| RLF | 4.65826687298153e-05 | ANAPC5/EIF4E2/MRPL3/MRPL58/NDUFS3/NDUFS7/PSMA1/SLX9 |
| ALKBH3 | 0.00163190543184927 | DDX1/EIF4E2/MRPL3/MRPL58/NDUFS7/SLX9/VPS25 |
| ZNF85 | 0.0251523044088028 | ABRACL/NABP2/NDUFS3/NDUFS7/VPS25 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_8_2 | R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 4/41 | 52/11146 | 3.75468428880581e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 4/41 | 52/11146 | 3.75468428880581e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-69610 | p53-Independent DNA Damage Response | 4/41 | 52/11146 | 3.75468428880581e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint | 4/41 | 52/11146 | 3.75468428880581e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 4/41 | 52/11146 | 3.75468428880581e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4/41 | 52/11146 | 3.75468428880581e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-169911 | Regulation of Apoptosis | 4/41 | 53/11146 | 4.05042004623466e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 4/41 | 54/11146 | 4.36285435671706e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| reactome | B_8_2 | R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4/41 | 54/11146 | 4.36285435671706e-05 | 0.00039465663529736 | 0.0002317784475591 | PSMA1/PSMB5/PSMC1/PSMD9 | 4 |
| GO | B_8_2 | GO:0072522 | purine-containing compound biosynthetic process | 6/47 | 263/18986 | 4.45074215072222e-05 | 0.00071656948626627 | 0.00059148020687229 | NDUFA11/NDUFA8/NDUFB9/NDUFS3/NDUFS7/NDUFV1 | 6 |