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Selected Module: B_5_2
Module Info
| Module_Name | B_5_2 |
| Cell_Type | B |
| Name | B_5_2: Protein processing in endoplasmic reticulum |
| Meta_Module | B_2 |
| Gene_Number | 40 |
Genes:
ACADVL, ARMCX3, CD27, CHID1, CHST12, DNAJB9, EDEM1, FBH1, GALNT2, GLT8D1, IFNAR2, JCHAIN, KDELR2, KRTCAP2, LMO4, MAN1A2, MANF, MEI1, NMRK1, OSTC, PDIA3, PIM2, PLD3, RRBP1, SDF2L1, SDF4, SEC14L1, SERP1, SLC38A10, SPATS2, SSR4, TAPBPL, TENT5C, TM9SF2, TMEM59, TPST2, TXNDC11, UBXN4, WDR45, XBP1
UMAP Visualizations
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Enriched TF
No TF enriched
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| KEGG | B_5_2 | hsa04141 | Protein processing in endoplasmic reticulum | 8/18 | 170/8541 | 7.71824382063411e-10 | 3.16447996645999e-08 | 3.0060528564575e-08 | EDEM1/MAN1A2/OSTC/PDIA3/RRBP1/SSR4/UBXN4/XBP1 | 8 |
| GO | B_5_2 | GO:0034976 | response to endoplasmic reticulum stress | 9/36 | 277/18986 | 1.75457937928746e-09 | 1.2457513592941e-06 | 1.03058451962358e-06 | DNAJB9/EDEM1/MAN1A2/MANF/PDIA3/SDF2L1/SERP1/UBXN4/XBP1 | 9 |
| GO | B_5_2 | GO:0035966 | response to topologically incorrect protein | 7/36 | 160/18986 | 1.79883949481937e-08 | 6.38588020660876e-06 | 5.28290756899583e-06 | DNAJB9/EDEM1/MANF/SDF2L1/SERP1/UBXN4/XBP1 | 7 |
| GO | B_5_2 | GO:0009100 | glycoprotein metabolic process | 9/36 | 392/18986 | 3.57739342593742e-08 | 8.46649777471855e-06 | 7.00415976025642e-06 | CHST12/EDEM1/GALNT2/KRTCAP2/MAN1A2/OSTC/SERP1/TM9SF2/TMEM59 | 9 |
| reactome | B_5_2 | R-HSA-381038 | XBP1(S) activates chaperone genes | 5/23 | 50/11146 | 4.68465046005338e-08 | 2.14908712906211e-06 | 1.65894445050409e-06 | ACADVL/DNAJB9/EDEM1/SERP1/XBP1 | 5 |
| reactome | B_5_2 | R-HSA-381070 | IRE1alpha activates chaperones | 5/23 | 52/11146 | 5.73089901083229e-08 | 2.14908712906211e-06 | 1.65894445050409e-06 | ACADVL/DNAJB9/EDEM1/SERP1/XBP1 | 5 |
| GO | B_5_2 | GO:0036503 | ERAD pathway | 6/36 | 113/18986 | 6.54770060242293e-08 | 1.16221685693007e-05 | 9.6147814109263e-06 | DNAJB9/EDEM1/MAN1A2/SDF2L1/UBXN4/XBP1 | 6 |
| GO | B_5_2 | GO:0140534 | endoplasmic reticulum protein-containing complex | 6/39 | 116/19960 | 9.43607344327499e-08 | 6.88833361359075e-06 | 5.06568153270552e-06 | KRTCAP2/OSTC/PDIA3/SDF2L1/SSR4/TAPBPL | 6 |
| GO | B_5_2 | GO:0009101 | glycoprotein biosynthetic process | 8/36 | 322/18986 | 1.25607016778725e-07 | 1.78361963825789e-05 | 1.47555190236902e-05 | CHST12/GALNT2/KRTCAP2/MAN1A2/OSTC/SERP1/TM9SF2/TMEM59 | 8 |
| GO | B_5_2 | GO:0006986 | response to unfolded protein | 6/36 | 143/18986 | 2.65699841761843e-07 | 3.14411479418181e-05 | 2.60106160882647e-05 | DNAJB9/EDEM1/MANF/SERP1/UBXN4/XBP1 | 6 |