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Selected Module: B_5_1
Module Info
| Module_Name | B_5_1 |
| Cell_Type | B |
| Name | B_5_1: Parkinson disease |
| Meta_Module | B_3 |
| Gene_Number | 42 |
Genes:
ADRM1, AHCY, ATG3, ATP5MC1, CALM3, CLPP, COX5B, EIF2S1, ELOC, ETFB, GTF3C6, LAGE3, MRPL27, MRPL37, MRPL41, MRPL57, MRPS15, MRPS34, MTCH2, NDUFA6, NUDT21, PDHA1, PGAM1, PRDX3, PRDX6, PSMA3, PSMA4, PSMB4, PSMB6, PSMC3, PSMD1, PSMD11, PSMD3, PSMD7, SLC25A11, SNF8, SUCLG1, TIMM8B, TMEM126A, TRAPPC2L, TXNL4A, VDAC3
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| TGASTMAGC | 0.0393301650202121 | PSMA3/PSMD1/PSMD11/PSMD7 |
| TGACCTTG | 0.0393301650202121 | ATP5MC1/COX5B/MTCH2/TIMM8B |
| SF1 | 0.0393301650202121 | ATP5MC1/COX5B/MTCH2/TIMM8B |
| ZMYM2 | 0.0468821792425049 | ADRM1/AHCY/CALM3 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| MeSH_gene2pubmed | B_5_1 | D003374 | Coumarins | 3/42 | 167/26076 | 0.00246562932750019 | 0.0434252675435238 | 0.0363885574219684 | EIF2S1/PSMB6/PSMC3 | 3 |
| GO | B_5_1 | GO:1990204 | oxidoreductase complex | 3/42 | 150/19960 | 0.00385335021800729 | 0.0169547409592321 | 0.00973477949812367 | COX5B/NDUFA6/PDHA1 | 3 |
| KEGG | B_5_1 | hsa00020 | Citrate cycle (TCA cycle) | 2/28 | 30/8541 | 0.00425982172726201 | 0.0356275999007368 | 0.0293499678816139 | PDHA1/SUCLG1 | 2 |
| KEGG | B_5_1 | hsa04922 | Glucagon signaling pathway | 3/28 | 107/8541 | 0.00498706166613925 | 0.0382341394404009 | 0.0314972315756163 | CALM3/PDHA1/PGAM1 | 3 |
| reactome | B_5_1 | R-HSA-9837999 | Mitochondrial protein degradation | 3/41 | 98/11146 | 0.00551624299751302 | 0.0130277228239137 | 0.0072891004894349 | CLPP/COX5B/PDHA1 | 3 |
| KEGG | B_5_1 | hsa05208 | Chemical carcinogenesis - reactive oxygen species | 4/28 | 227/8541 | 0.00602627336945626 | 0.0410344604360087 | 0.0338041321669637 | ATP5MC1/COX5B/NDUFA6/VDAC3 | 4 |
| KEGG | B_5_1 | hsa01200 | Carbon metabolism | 3/28 | 116/8541 | 0.00624437441417524 | 0.0410344604360087 | 0.0338041321669637 | PDHA1/PGAM1/SUCLG1 | 3 |
| reactome | B_5_1 | R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 2/41 | 37/11146 | 0.00810496743142495 | 0.0190067193990458 | 0.0106343901805946 | PRDX3/PRDX6 | 2 |
| GO | B_5_1 | GO:0015935 | small ribosomal subunit | 2/42 | 74/19960 | 0.0106082943269867 | 0.0448812452295593 | 0.0257691360169718 | MRPS15/MRPS34 | 2 |