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Selected Module: B_5_1
Module Info
| Module_Name | B_5_1 |
| Cell_Type | B |
| Name | B_5_1: Parkinson disease |
| Meta_Module | B_3 |
| Gene_Number | 42 |
Genes:
ADRM1, AHCY, ATG3, ATP5MC1, CALM3, CLPP, COX5B, EIF2S1, ELOC, ETFB, GTF3C6, LAGE3, MRPL27, MRPL37, MRPL41, MRPL57, MRPS15, MRPS34, MTCH2, NDUFA6, NUDT21, PDHA1, PGAM1, PRDX3, PRDX6, PSMA3, PSMA4, PSMB4, PSMB6, PSMC3, PSMD1, PSMD11, PSMD3, PSMD7, SLC25A11, SNF8, SUCLG1, TIMM8B, TMEM126A, TRAPPC2L, TXNL4A, VDAC3
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| TGASTMAGC | 0.0393301650202121 | PSMA3/PSMD1/PSMD11/PSMD7 |
| TGACCTTG | 0.0393301650202121 | ATP5MC1/COX5B/MTCH2/TIMM8B |
| SF1 | 0.0393301650202121 | ATP5MC1/COX5B/MTCH2/TIMM8B |
| ZMYM2 | 0.0468821792425049 | ADRM1/AHCY/CALM3 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_5_1 | GO:0007005 | mitochondrion organization | 7/42 | 452/18986 | 5.42857270557535e-05 | 0.00639729701457537 | 0.00508978936622174 | ATG3/CLPP/MTCH2/NDUFA6/PRDX3/TIMM8B/TMEM126A | 7 |
| GO | B_5_1 | GO:0090151 | establishment of protein localization to mitochondrial membrane | 3/42 | 34/18986 | 5.74263645832619e-05 | 0.00639729701457537 | 0.00508978936622174 | MTCH2/TIMM8B/TMEM126A | 3 |
| reactome | B_5_1 | R-HSA-72766 | Translation | 7/41 | 292/11146 | 8.24859953020375e-05 | 0.00020049515646407 | 0.00011217841850526 | EIF2S1/MRPL27/MRPL37/MRPL41/MRPL57/MRPS15/MRPS34 | 7 |
| GO | B_5_1 | GO:0006091 | generation of precursor metabolites and energy | 7/42 | 490/18986 | 9.01123808709163e-05 | 0.00836543269085006 | 0.00665566883274662 | ATG3/COX5B/ETFB/NDUFA6/PDHA1/PGAM1/SUCLG1 | 7 |
| GO | B_5_1 | GO:0015934 | large ribosomal subunit | 4/42 | 114/19960 | 9.55478112345645e-05 | 0.00055317153872642 | 0.00031761045285727 | MRPL27/MRPL37/MRPL41/MRPL57 | 4 |
| GO | B_5_1 | GO:0015980 | energy derivation by oxidation of organic compounds | 6/42 | 356/18986 | 0.00012361910477481 | 0.00983654876565289 | 0.00782611174589411 | ATG3/COX5B/ETFB/NDUFA6/PDHA1/SUCLG1 | 6 |
| MeSH_gene2pubmed | B_5_1 | D008929 | Mitochondria, Heart | 4/42 | 173/26076 | 0.00017202835148522 | 0.00390685440346699 | 0.00327378053934478 | COX5B/NDUFA6/PDHA1/SLC25A11 | 4 |
| GO | B_5_1 | GO:0045333 | cellular respiration | 5/42 | 249/18986 | 0.00021333383611193 | 0.0148533683392935 | 0.0118175717109375 | COX5B/ETFB/NDUFA6/PDHA1/SUCLG1 | 5 |
| GO | B_5_1 | GO:0019774 | proteasome core complex, beta-subunit complex | 2/42 | 11/19960 | 0.00023489471451573 | 0.00129192092983654 | 0.00074177278268126 | PSMB4/PSMB6 | 2 |
| reactome | B_5_1 | R-HSA-611105 | Respiratory electron transport | 5/41 | 158/11146 | 0.00026663689484811 | 0.00064340642017696 | 0.00035999031569882 | COX5B/ETFB/NDUFA6/SLC25A11/TMEM126A | 5 |