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Selected Module: B_5_1
Module Info
| Module_Name | B_5_1 |
| Cell_Type | B |
| Name | B_5_1: Parkinson disease |
| Meta_Module | B_3 |
| Gene_Number | 42 |
Genes:
ADRM1, AHCY, ATG3, ATP5MC1, CALM3, CLPP, COX5B, EIF2S1, ELOC, ETFB, GTF3C6, LAGE3, MRPL27, MRPL37, MRPL41, MRPL57, MRPS15, MRPS34, MTCH2, NDUFA6, NUDT21, PDHA1, PGAM1, PRDX3, PRDX6, PSMA3, PSMA4, PSMB4, PSMB6, PSMC3, PSMD1, PSMD11, PSMD3, PSMD7, SLC25A11, SNF8, SUCLG1, TIMM8B, TMEM126A, TRAPPC2L, TXNL4A, VDAC3
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| TGASTMAGC | 0.0393301650202121 | PSMA3/PSMD1/PSMD11/PSMD7 |
| TGACCTTG | 0.0393301650202121 | ATP5MC1/COX5B/MTCH2/TIMM8B |
| SF1 | 0.0393301650202121 | ATP5MC1/COX5B/MTCH2/TIMM8B |
| ZMYM2 | 0.0468821792425049 | ADRM1/AHCY/CALM3 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_5_1 | GO:0140053 | mitochondrial gene expression | 6/42 | 169/18986 | 1.83068200064108e-06 | 0.00033989662478569 | 0.00027042706044557 | MRPL27/MRPL37/MRPL41/MRPL57/MRPS15/MRPS34 | 6 |
| GO | B_5_1 | GO:0044391 | ribosomal subunit | 6/42 | 186/19960 | 2.39761251493411e-06 | 2.63737376642752e-05 | 1.51428158837944e-05 | MRPL27/MRPL37/MRPL41/MRPL57/MRPS15/MRPS34 | 6 |
| GO | B_5_1 | GO:0003735 | structural constituent of ribosome | 6/42 | 175/18737 | 2.41789391883788e-06 | 0.00026113254323449 | 0.00020106696798757 | MRPL27/MRPL37/MRPL41/MRPL57/MRPS15/MRPS34 | 6 |
| WikiPathways | B_5_1 | WP2359 | Parkin ubiquitin proteasomal system pathway | 5/29 | 71/8836 | 2.96892341830931e-06 | 5.41828523841449e-05 | 4.37525556382424e-05 | PSMC3/PSMD1/PSMD11/PSMD3/PSMD7 | 5 |
| reactome | B_5_1 | R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8/41 | 260/11146 | 3.8603725697883e-06 | 9.66544410330455e-06 | 5.40788242859145e-06 | ATP5MC1/COX5B/ETFB/NDUFA6/PDHA1/SLC25A11/SUCLG1/TMEM126A | 8 |
| GO | B_5_1 | GO:0034774 | secretory granule lumen | 7/42 | 324/19960 | 4.61013324346004e-06 | 4.15139739577909e-05 | 2.38357745212197e-05 | PGAM1/PRDX6/PSMC3/PSMD1/PSMD11/PSMD3/PSMD7 | 7 |
| reactome | B_5_1 | R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 10/41 | 464/11146 | 4.97187425274367e-06 | 1.235547855346e-05 | 6.91297519823746e-06 | CALM3/PSMA3/PSMA4/PSMB4/PSMB6/PSMC3/PSMD1/PSMD11/PSMD3/PSMD7 | 10 |
| GO | B_5_1 | GO:0060205 | cytoplasmic vesicle lumen | 7/42 | 329/19960 | 5.09738979696922e-06 | 4.15139739577909e-05 | 2.38357745212197e-05 | PGAM1/PRDX6/PSMC3/PSMD1/PSMD11/PSMD3/PSMD7 | 7 |
| GO | B_5_1 | GO:0031983 | vesicle lumen | 7/42 | 330/19960 | 5.19981805873782e-06 | 4.15139739577909e-05 | 2.38357745212197e-05 | PGAM1/PRDX6/PSMC3/PSMD1/PSMD11/PSMD3/PSMD7 | 7 |
| GO | B_5_1 | GO:0000315 | organellar large ribosomal subunit | 4/42 | 56/19960 | 5.74442201249241e-06 | 4.15139739577909e-05 | 2.38357745212197e-05 | MRPL27/MRPL37/MRPL41/MRPL57 | 4 |