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Selected Module: B_4_1
Module Info
| Module_Name | B_4_1 |
| Cell_Type | B |
| Name | B_4_1: oxidative phosphorylation |
| Meta_Module | B_3 |
| Gene_Number | 40 |
Genes:
ANAPC11, ATP5F1C, ATP5MC3, ATP5ME, ATP5MF, ATP5PF, AURKAIP1, BOLA3, CHCHD2, COPS9, COX17, COX6C, COX8A, ELOB, MDH2, MIF, MMADHC, MRPS16, MRPS33, MRPS7, NDUFA2, NDUFB10, NDUFB6, NDUFC1, NDUFS5, NOP10, PARK7, POLDIP2, POP7, PPA1, PRDX1, PSMB1, PSMB2, RPL26L1, RPS19BP1, TUFM, TXN, UQCRC1, UQCRH, ZNHIT1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| SRPK1 | 0.00319087597481954 | ATP5F1C/AURKAIP1/MDH2/MRPS7/POP7/PRDX1 |
| TGACCTTG | 0.032145093571554 | ATP5F1C/ATP5MC3/ATP5PF/UQCRC1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_4_1 | GO:0006091 | generation of precursor metabolites and energy | 17/40 | 490/18986 | 3.90176696389233e-17 | 4.16374274575367e-15 | 3.18595407728351e-15 | ATP5F1C/ATP5ME/ATP5MF/ATP5PF/CHCHD2/COX17/COX6C/COX8A/MDH2/NDUFA2/NDUFB10/NDUFB6/NDUFC1/NDUFS5/PARK7/UQCRC1/UQCRH | 17 |
| GO | B_4_1 | GO:0022900 | electron transport chain | 12/40 | 135/18986 | 4.78479256151632e-17 | 4.46780005431586e-15 | 3.41860836960969e-15 | CHCHD2/COX6C/COX8A/MDH2/NDUFA2/NDUFB10/NDUFB6/NDUFC1/NDUFS5/PARK7/UQCRC1/UQCRH | 12 |
| GO | B_4_1 | GO:0015078 | proton transmembrane transporter activity | 13/40 | 185/18737 | 5.27822161068022e-17 | 4.9615283140394e-15 | 3.33361364885066e-15 | ATP5F1C/ATP5MC3/ATP5ME/ATP5MF/ATP5PF/COX8A/NDUFA2/NDUFB10/NDUFB6/NDUFC1/NDUFS5/UQCRC1/UQCRH | 13 |
| GO | B_4_1 | GO:0042773 | ATP synthesis coupled electron transport | 11/40 | 101/18986 | 1.12185779891129e-16 | 8.38027775786731e-15 | 6.41230299798767e-15 | CHCHD2/COX6C/COX8A/NDUFA2/NDUFB10/NDUFB6/NDUFC1/NDUFS5/PARK7/UQCRC1/UQCRH | 11 |
| GO | B_4_1 | GO:0042775 | mitochondrial ATP synthesis coupled electron transport | 11/40 | 101/18986 | 1.12185779891129e-16 | 8.38027775786731e-15 | 6.41230299798767e-15 | CHCHD2/COX6C/COX8A/NDUFA2/NDUFB10/NDUFB6/NDUFC1/NDUFS5/PARK7/UQCRC1/UQCRH | 11 |
| KEGG | B_4_1 | hsa05012 | Parkinson disease | 16/32 | 271/8541 | 2.59347454869141e-16 | 5.18694909738282e-15 | 3.27596785097862e-15 | ATP5F1C/ATP5MC3/ATP5PF/COX6C/COX8A/NDUFA2/NDUFB10/NDUFB6/NDUFC1/NDUFS5/PARK7/PSMB1/PSMB2/TXN/UQCRC1/UQCRH | 16 |
| GO | B_4_1 | GO:0015986 | proton motive force-driven ATP synthesis | 10/40 | 77/18986 | 5.04642277907277e-16 | 3.4269798326976e-14 | 2.62220820003494e-14 | ATP5F1C/ATP5MC3/ATP5ME/ATP5MF/ATP5PF/NDUFA2/NDUFB10/NDUFB6/NDUFC1/NDUFS5 | 10 |
| KEGG | B_4_1 | hsa04714 | Thermogenesis | 15/32 | 235/8541 | 9.38328272935011e-16 | 1.25110436391335e-14 | 7.9017117720843e-15 | ATP5F1C/ATP5MC3/ATP5ME/ATP5MF/ATP5PF/COX17/COX6C/COX8A/NDUFA2/NDUFB10/NDUFB6/NDUFC1/NDUFS5/UQCRC1/UQCRH | 15 |
| GO | B_4_1 | GO:0019646 | aerobic electron transport chain | 10/40 | 93/18986 | 3.63194114478862e-15 | 2.26088336263091e-13 | 1.72995091370195e-13 | COX6C/COX8A/NDUFA2/NDUFB10/NDUFB6/NDUFC1/NDUFS5/PARK7/UQCRC1/UQCRH | 10 |
| GO | B_4_1 | GO:0006754 | ATP biosynthetic process | 10/40 | 100/18986 | 7.70330975067288e-15 | 4.42644029519434e-13 | 3.38696129118654e-13 | ATP5F1C/ATP5MC3/ATP5ME/ATP5MF/ATP5PF/NDUFA2/NDUFB10/NDUFB6/NDUFC1/NDUFS5 | 10 |