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Selected Module: B_4_1
Module Info
| Module_Name | B_4_1 |
| Cell_Type | B |
| Name | B_4_1: oxidative phosphorylation |
| Meta_Module | B_3 |
| Gene_Number | 40 |
Genes:
ANAPC11, ATP5F1C, ATP5MC3, ATP5ME, ATP5MF, ATP5PF, AURKAIP1, BOLA3, CHCHD2, COPS9, COX17, COX6C, COX8A, ELOB, MDH2, MIF, MMADHC, MRPS16, MRPS33, MRPS7, NDUFA2, NDUFB10, NDUFB6, NDUFC1, NDUFS5, NOP10, PARK7, POLDIP2, POP7, PPA1, PRDX1, PSMB1, PSMB2, RPL26L1, RPS19BP1, TUFM, TXN, UQCRC1, UQCRH, ZNHIT1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| SRPK1 | 0.00319087597481954 | ATP5F1C/AURKAIP1/MDH2/MRPS7/POP7/PRDX1 |
| TGACCTTG | 0.032145093571554 | ATP5F1C/ATP5MC3/ATP5PF/UQCRC1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_4_1 | R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3/36 | 72/11146 | 0.00158377574790665 | 0.0165407524501215 | 0.0095092584935921 | ANAPC11/PSMB1/PSMB2 | 3 |
| reactome | B_4_1 | R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 3/36 | 73/11146 | 0.00164800373937373 | 0.0165407524501215 | 0.0095092584935921 | ANAPC11/PSMB1/PSMB2 | 3 |
| reactome | B_4_1 | R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 3/36 | 73/11146 | 0.00164800373937373 | 0.0165407524501215 | 0.0095092584935921 | ANAPC11/PSMB1/PSMB2 | 3 |
| reactome | B_4_1 | R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 2/36 | 19/11146 | 0.00167555253481959 | 0.0165407524501215 | 0.0095092584935921 | PRDX1/TXN | 2 |
| GO | B_4_1 | GO:0000305 | response to oxygen radical | 2/40 | 29/18986 | 0.00169501844984019 | 0.0214606573225529 | 0.016420963751351 | PARK7/PRDX1 | 2 |
| MeSH_gene2pubmed | B_4_1 | D015227 | Lipid Peroxidation | 4/39 | 348/26076 | 0.00177400121772429 | 0.0463836415951328 | 0.0391236725552033 | PARK7/TXN/UQCRC1/UQCRH | 4 |
| reactome | B_4_1 | R-HSA-1234174 | Cellular response to hypoxia | 3/36 | 75/11146 | 0.00178131180232077 | 0.0165407524501215 | 0.0095092584935921 | ELOB/PSMB1/PSMB2 | 3 |
| reactome | B_4_1 | R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3/36 | 75/11146 | 0.00178131180232077 | 0.0165407524501215 | 0.0095092584935921 | ANAPC11/PSMB1/PSMB2 | 3 |
| reactome | B_4_1 | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3/36 | 76/11146 | 0.00185042125406278 | 0.0165899836571146 | 0.00953756145469744 | ANAPC11/PSMB1/PSMB2 | 3 |
| GO | B_4_1 | GO:0034599 | cellular response to oxidative stress | 4/40 | 251/18986 | 0.00187555927760974 | 0.0233507130062413 | 0.0178671699603876 | CHCHD2/PARK7/PRDX1/TXN | 4 |