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Selected Module: B_3_1
Module Info
| Module_Name | B_3_1 |
| Cell_Type | B |
| Name | B_3_1: Protein processing in endoplasmic reticulum |
| Meta_Module | B_2 |
| Gene_Number | 47 |
Genes:
ALG5, ARF4, ARFGAP3, ATF4, B4GALT3, CD59, COPG1, DAD1, DDOST, DERL1, DERL2, DERL3, DNAJC1, ERGIC3, ERLEC1, FKBP2, HM13, IDH2, ISG20, ITM2C, KDELR1, KLF13, LRPAP1, MGAT1, MORF4L2, NUCB1, NUCB2, OS9, P4HB, RPN1, RPN2, SAR1B, SEC61A1, SEC61B, SRP54, SRPRA, SRPRB, SSR1, SSR2, ST6GALNAC4, TMBIM6, TMCO1, TMEM208, TNFRSF17, TXNDC15, UBE2J1, ZBP1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| XBP1 | 0.00087721865727556 | ARFGAP3/KDELR1/MORF4L2/SEC61A1/SRPRA |
| HTF | 0.00088044164334352 | HM13/MORF4L2/SEC61A1/SRP54 |
| STAT1 | 0.0049985900069652 | DDOST/ITM2C/MORF4L2/NUCB1/TMCO1 |
| GABP | 0.0049985900069652 | DDOST/DERL1/SRP54/TMCO1/TMEM208 |
| NRF2 | 0.0049985900069652 | DDOST/DNAJC1/ITM2C/TMCO1/TMEM208 |
| FOXO4 | 0.0206509811700283 | COPG1/ERLEC1/FKBP2/SRP54/TMCO1 |
| FOXR2 | 0.0239983226037003 | HM13/P4HB/SRP54/SSR2 |
| GGAANCGGAANY | 0.0249993647968756 | SEC61A1/SRP54/TMCO1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_3_1 | GO:0034620 | cellular response to unfolded protein | 7/47 | 99/18986 | 4.48196235303541e-09 | 1.41679809937619e-07 | 1.1060749198719e-07 | ATF4/DERL1/DERL2/DERL3/ERLEC1/OS9/TMBIM6 | 7 |
| GO | B_3_1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 5/47 | 27/18986 | 5.78699199175938e-09 | 1.73305181226899e-07 | 1.35296987286563e-07 | SEC61A1/SEC61B/SRP54/SRPRA/SRPRB | 5 |
| GO | B_3_1 | GO:0043021 | ribonucleoprotein complex binding | 8/47 | 174/18737 | 1.08707103095911e-08 | 1.39145091962766e-06 | 1.01841391321433e-06 | DERL1/DERL2/DERL3/SEC61A1/SEC61B/SRP54/SRPRA/TMCO1 | 8 |
| GO | B_3_1 | GO:0035967 | cellular response to topologically incorrect protein | 7/47 | 114/18986 | 1.20490294573374e-08 | 3.4279488806125e-07 | 2.67615285841916e-07 | ATF4/DERL1/DERL2/DERL3/ERLEC1/OS9/TMBIM6 | 7 |
| GO | B_3_1 | GO:0090317 | negative regulation of intracellular protein transport | 5/47 | 32/18986 | 1.43027195941514e-08 | 3.8753559281296e-07 | 3.02543742793579e-07 | DERL2/DERL3/ERLEC1/OS9/UBE2J1 | 5 |
| KEGG | B_3_1 | hsa00513 | Various types of N-glycan biosynthesis | 6/36 | 42/8541 | 1.70289897205435e-08 | 2.98007320109511e-07 | 2.91285350482981e-07 | B4GALT3/DAD1/DDOST/MGAT1/RPN1/RPN2 | 6 |
| reactome | B_3_1 | R-HSA-72766 | Translation | 10/36 | 292/11146 | 1.81673623518866e-08 | 5.2231166761674e-07 | 3.25100168402182e-07 | DDOST/RPN1/RPN2/SEC61A1/SEC61B/SRP54/SRPRA/SRPRB/SSR1/SSR2 | 10 |
| reactome | B_3_1 | R-HSA-9694635 | Translation of Structural Proteins | 6/36 | 57/11146 | 2.36204341962214e-08 | 5.43269986513091e-07 | 3.38145163230116e-07 | DAD1/DDOST/MGAT1/RPN1/RPN2/ST6GALNAC4 | 6 |
| GO | B_3_1 | GO:0008250 | oligosaccharyltransferase complex | 4/47 | 14/19960 | 2.65430970235376e-08 | 4.93701604637799e-07 | 3.35281225560474e-07 | DAD1/DDOST/RPN1/RPN2 | 4 |
| GO | B_3_1 | GO:0006612 | protein targeting to membrane | 7/47 | 129/18986 | 2.84674091521114e-08 | 7.36270718525063e-07 | 5.74796491013924e-07 | SEC61A1/SEC61B/SRP54/SRPRA/SRPRB/SSR1/SSR2 | 7 |