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Selected Module: B_3_1


Module Info

Module_Name B_3_1
Cell_Type B
Name B_3_1: Protein processing in endoplasmic reticulum
Meta_Module B_2
Gene_Number 47

Genes:

ALG5, ARF4, ARFGAP3, ATF4, B4GALT3, CD59, COPG1, DAD1, DDOST, DERL1, DERL2, DERL3, DNAJC1, ERGIC3, ERLEC1, FKBP2, HM13, IDH2, ISG20, ITM2C, KDELR1, KLF13, LRPAP1, MGAT1, MORF4L2, NUCB1, NUCB2, OS9, P4HB, RPN1, RPN2, SAR1B, SEC61A1, SEC61B, SRP54, SRPRA, SRPRB, SSR1, SSR2, ST6GALNAC4, TMBIM6, TMCO1, TMEM208, TNFRSF17, TXNDC15, UBE2J1, ZBP1


UMAP Visualizations


UMAP for B_3_1

UMAP for B_3_1


Word Cloud

Enriched TF

Wordcloud for B_3_1
TF p.adjust Genes
XBP1 0.00087721865727556 ARFGAP3/KDELR1/MORF4L2/SEC61A1/SRPRA
HTF 0.00088044164334352 HM13/MORF4L2/SEC61A1/SRP54
STAT1 0.0049985900069652 DDOST/ITM2C/MORF4L2/NUCB1/TMCO1
GABP 0.0049985900069652 DDOST/DERL1/SRP54/TMCO1/TMEM208
NRF2 0.0049985900069652 DDOST/DNAJC1/ITM2C/TMCO1/TMEM208
FOXO4 0.0206509811700283 COPG1/ERLEC1/FKBP2/SRP54/TMCO1
FOXR2 0.0239983226037003 HM13/P4HB/SRP54/SSR2
GGAANCGGAANY 0.0249993647968756 SEC61A1/SRP54/TMCO1


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
GO B_3_1 GO:0042277 peptide binding 5/47 249/18737 0.00038730319001334 0.00991496166434167 0.00725683871814481 ITM2C/KDELR1/LRPAP1/SEC61A1/SRP54 5
GO B_3_1 GO:1990253 cellular response to leucine starvation 2/47 12/18986 0.00038966550767132 0.00515627148523212 0.0040254307034834 ATF4/SAR1B 2
reactome B_3_1 R-HSA-8963888 Chylomicron assembly 2/36 10/11146 0.00044907061605043 0.00258215604228997 0.00160720009954891 P4HB/SAR1B 2
GO B_3_1 GO:0035437 maintenance of protein localization in endoplasmic reticulum 2/47 13/18986 0.00045978719762121 0.0059458844419652 0.00464187075110409 KDELR1/OS9 2
MeSH_gene2pubmed B_3_1 D020727 ADP-Ribosylation Factors 5/47 360/26076 0.00046485852512441 0.0201879523307206 0.0181355232505243 ARF4/ARFGAP3/COPG1/KDELR1/SEC61B 5
MeSH_gene2pubmed B_3_1 D020673 Protein Renaturation 3/47 84/26076 0.00047202046816433 0.0201879523307206 0.0181355232505243 P4HB/SEC61A1/SEC61B 3
MeSH_gene2pubmed B_3_1 D051702 Activating Transcription Factor 6 3/47 84/26076 0.00047202046816433 0.0201879523307206 0.0181355232505243 ATF4/NUCB1/SAR1B 3
reactome B_3_1 R-HSA-381038 XBP1(S) activates chaperone genes 3/36 50/11146 0.00054646151006503 0.00299252731702281 0.00186262569846729 SRPRA/SRPRB/SSR1 3
reactome B_3_1 R-HSA-381070 IRE1alpha activates chaperones 3/36 52/11146 0.00061343941854653 0.00320661514240236 0.00199587944790261 SRPRA/SRPRB/SSR1 3
GO B_3_1 GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane 2/47 15/18986 0.0006169932104166 0.00780153637171217 0.00609055286072063 SEC61A1/SEC61B 2