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Selected Module: B_3_1
Module Info
| Module_Name | B_3_1 |
| Cell_Type | B |
| Name | B_3_1: Protein processing in endoplasmic reticulum |
| Meta_Module | B_2 |
| Gene_Number | 47 |
Genes:
ALG5, ARF4, ARFGAP3, ATF4, B4GALT3, CD59, COPG1, DAD1, DDOST, DERL1, DERL2, DERL3, DNAJC1, ERGIC3, ERLEC1, FKBP2, HM13, IDH2, ISG20, ITM2C, KDELR1, KLF13, LRPAP1, MGAT1, MORF4L2, NUCB1, NUCB2, OS9, P4HB, RPN1, RPN2, SAR1B, SEC61A1, SEC61B, SRP54, SRPRA, SRPRB, SSR1, SSR2, ST6GALNAC4, TMBIM6, TMCO1, TMEM208, TNFRSF17, TXNDC15, UBE2J1, ZBP1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| XBP1 | 0.00087721865727556 | ARFGAP3/KDELR1/MORF4L2/SEC61A1/SRPRA |
| HTF | 0.00088044164334352 | HM13/MORF4L2/SEC61A1/SRP54 |
| STAT1 | 0.0049985900069652 | DDOST/ITM2C/MORF4L2/NUCB1/TMCO1 |
| GABP | 0.0049985900069652 | DDOST/DERL1/SRP54/TMCO1/TMEM208 |
| NRF2 | 0.0049985900069652 | DDOST/DNAJC1/ITM2C/TMCO1/TMEM208 |
| FOXO4 | 0.0206509811700283 | COPG1/ERLEC1/FKBP2/SRP54/TMCO1 |
| FOXR2 | 0.0239983226037003 | HM13/P4HB/SRP54/SSR2 |
| GGAANCGGAANY | 0.0249993647968756 | SEC61A1/SRP54/TMCO1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| KEGG | B_3_1 | hsa04141 | Protein processing in endoplasmic reticulum | 18/36 | 170/8541 | 6.43089945358508e-22 | 4.50162961750956e-20 | 4.40008909982137e-20 | ATF4/DAD1/DDOST/DERL1/DERL2/DERL3/DNAJC1/ERLEC1/OS9/P4HB/RPN1/RPN2/SAR1B/SEC61A1/SEC61B/SSR1/SSR2/UBE2J1 | 18 |
| reactome | B_3_1 | R-HSA-446203 | Asparagine N-linked glycosylation | 17/36 | 306/11146 | 9.87233564356124e-18 | 1.13531859900954e-15 | 7.06651393433858e-16 | ALG5/ARF4/ARFGAP3/B4GALT3/CD59/COPG1/DAD1/DDOST/DERL1/DERL2/KDELR1/MGAT1/OS9/RPN1/RPN2/SAR1B/ST6GALNAC4 | 17 |
| GO | B_3_1 | GO:0140534 | endoplasmic reticulum protein-containing complex | 12/47 | 116/19960 | 3.6480406289438e-17 | 3.39267778491773e-15 | 2.30402566038556e-15 | DAD1/DDOST/DERL1/HM13/OS9/P4HB/RPN1/RPN2/SEC61A1/SEC61B/SRPRA/SRPRB | 12 |
| GO | B_3_1 | GO:0030970 | retrograde protein transport, ER to cytosol | 8/47 | 29/18986 | 3.10635201107336e-15 | 8.83757147150372e-13 | 6.89937130880505e-13 | DERL1/DERL2/DERL3/ERLEC1/HM13/OS9/SEC61B/UBE2J1 | 8 |
| GO | B_3_1 | GO:1903513 | endoplasmic reticulum to cytosol transport | 8/47 | 29/18986 | 3.10635201107336e-15 | 8.83757147150372e-13 | 6.89937130880505e-13 | DERL1/DERL2/DERL3/ERLEC1/HM13/OS9/SEC61B/UBE2J1 | 8 |
| GO | B_3_1 | GO:0018279 | protein N-linked glycosylation via asparagine | 8/47 | 43/18986 | 1.02292957078348e-13 | 1.94015641925267e-11 | 1.51465361007238e-11 | ALG5/DAD1/DDOST/DERL3/MGAT1/RPN1/RPN2/UBE2J1 | 8 |
| GO | B_3_1 | GO:0032527 | protein exit from endoplasmic reticulum | 8/47 | 47/18986 | 2.20209063559988e-13 | 3.13247392914083e-11 | 2.44547960058724e-11 | DERL1/DERL2/DERL3/ERLEC1/HM13/OS9/SEC61B/UBE2J1 | 8 |
| GO | B_3_1 | GO:0005791 | rough endoplasmic reticulum | 8/47 | 58/19960 | 8.85523208771276e-13 | 4.11768292078643e-11 | 2.79638908033035e-11 | ALG5/HM13/LRPAP1/RPN1/SEC61A1/SEC61B/SRPRA/SRPRB | 8 |
| GO | B_3_1 | GO:0006613 | cotranslational protein targeting to membrane | 7/47 | 32/18986 | 1.14688240125326e-12 | 1.30515217262621e-10 | 1.01891447016606e-10 | SEC61A1/SEC61B/SRP54/SRPRA/SRPRB/SSR1/SSR2 | 7 |
| reactome | B_3_1 | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 10/36 | 113/11146 | 1.56002569816784e-12 | 8.97014776446511e-11 | 5.58324986712702e-11 | DDOST/RPN1/RPN2/SEC61A1/SEC61B/SRP54/SRPRA/SRPRB/SSR1/SSR2 | 10 |