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Selected Module: B_14_24


Module Info

Module_Name B_14_24
Cell_Type B
Name B_14_24: DNA-templated DNA replication
Meta_Module B_9
Gene_Number 31

Genes:

ATAD5, CENPK, CHAF1A, CKAP5, CSE1L, DDX11, DHFR, FEN1, FN3KRP, GMNN, H2AC20, HELLS, LMNB1, MAD2L1, MIS18A, MMS22L, ORC6, PHF19, POLD3, PRIM1, RFC3, RFC4, RRM1, SAAL1, SKP2, TEX30, TOPBP1, TTF2, UBE2T, UNG, YEATS4


UMAP Visualizations


UMAP for B_14_24

UMAP for B_14_24


Word Cloud

Enriched TF

Wordcloud for B_14_24
TF p.adjust Genes
SGCGSSAAA 8.60315355022546e-05 ATAD5/GMNN/POLD3/TOPBP1/UNG
KTGGYRSGAA 8.60315355022546e-05 MMS22L/PRIM1/RFC4/TOPBP1
E2F1DP1RB 8.60315355022546e-05 ATAD5/GMNN/POLD3/TOPBP1/UNG
E2F 8.60315355022546e-05 ATAD5/GMNN/POLD3/TOPBP1/UNG
E2F1 8.60315355022546e-05 ATAD5/GMNN/POLD3/TOPBP1/UNG
E2F 8.60315355022546e-05 ATAD5/GMNN/POLD3/TOPBP1/UNG
E2F 8.60315355022546e-05 ATAD5/GMNN/POLD3/TOPBP1/UNG
E2F1DP1 8.60315355022546e-05 ATAD5/GMNN/POLD3/TOPBP1/UNG


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
GO B_14_24 GO:0072527 pyrimidine-containing compound metabolic process 2/30 74/18986 0.00607477956776028 0.0485982365420823 0.0315599753435424 RRM1/UNG 2
reactome B_14_24 R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 2/24 60/11146 0.00728842499717864 0.0224332042120953 0.0122553147594391 H2AC20/UNG 2
reactome B_14_24 R-HSA-110329 Cleavage of the damaged pyrimidine 2/24 60/11146 0.00728842499717864 0.0224332042120953 0.0122553147594391 H2AC20/UNG 2
reactome B_14_24 R-HSA-73928 Depyrimidination 2/24 60/11146 0.00728842499717864 0.0224332042120953 0.0122553147594391 H2AC20/UNG 2
reactome B_14_24 R-HSA-2467813 Separation of Sister Chromatids 3/24 190/11146 0.007581401735004 0.0230357975794352 0.0125845130014236 CENPK/CKAP5/MAD2L1 3
reactome B_14_24 R-HSA-73929 Base-Excision Repair, AP Site Formation 2/24 62/11146 0.00776631031178019 0.0232989309353406 0.0127282634023846 H2AC20/UNG 2
reactome B_14_24 R-HSA-68616 Assembly of the ORC complex at the origin of replication 2/24 68/11146 0.0092825373389502 0.0273121084522041 0.0149206721724233 H2AC20/ORC6 2
reactome B_14_24 R-HSA-68877 Mitotic Prometaphase 3/24 205/11146 0.0093345180786014 0.0273121084522041 0.0149206721724233 CENPK/CKAP5/MAD2L1 3
hallmark B_14_24 HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 4/19 200/4384 0.00949345935487037 0.0316448645162346 0.0233172685909097 CHAF1A/LMNB1/MAD2L1/ORC6 4
GO B_14_24 GO:0035861 site of double-strand break 2/30 99/19960 0.00967797998601391 0.0358654552422869 0.0197754389807095 MMS22L/TOPBP1 2