Module Explorer
Instructions
- Enter a module name.
- Click Submit to search for the detailed information of the module.
- Results will appear below if available.
Selected Module: B_14_24
Module Info
| Module_Name | B_14_24 |
| Cell_Type | B |
| Name | B_14_24: DNA-templated DNA replication |
| Meta_Module | B_9 |
| Gene_Number | 31 |
Genes:
ATAD5, CENPK, CHAF1A, CKAP5, CSE1L, DDX11, DHFR, FEN1, FN3KRP, GMNN, H2AC20, HELLS, LMNB1, MAD2L1, MIS18A, MMS22L, ORC6, PHF19, POLD3, PRIM1, RFC3, RFC4, RRM1, SAAL1, SKP2, TEX30, TOPBP1, TTF2, UBE2T, UNG, YEATS4
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| SGCGSSAAA | 8.60315355022546e-05 | ATAD5/GMNN/POLD3/TOPBP1/UNG |
| KTGGYRSGAA | 8.60315355022546e-05 | MMS22L/PRIM1/RFC4/TOPBP1 |
| E2F1DP1RB | 8.60315355022546e-05 | ATAD5/GMNN/POLD3/TOPBP1/UNG |
| E2F | 8.60315355022546e-05 | ATAD5/GMNN/POLD3/TOPBP1/UNG |
| E2F1 | 8.60315355022546e-05 | ATAD5/GMNN/POLD3/TOPBP1/UNG |
| E2F | 8.60315355022546e-05 | ATAD5/GMNN/POLD3/TOPBP1/UNG |
| E2F | 8.60315355022546e-05 | ATAD5/GMNN/POLD3/TOPBP1/UNG |
| E2F1DP1 | 8.60315355022546e-05 | ATAD5/GMNN/POLD3/TOPBP1/UNG |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_14_24 | R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3/24 | 40/11146 | 8.22544591577025e-05 | 0.00056766560886498 | 0.0003101171214319 | RFC3/RFC4/TOPBP1 | 3 |
| reactome | B_14_24 | R-HSA-5696400 | Dual Incision in GG-NER | 3/24 | 41/11146 | 8.86229009620436e-05 | 0.00056766560886498 | 0.0003101171214319 | POLD3/RFC3/RFC4 | 3 |
| reactome | B_14_24 | R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3/24 | 41/11146 | 8.86229009620436e-05 | 0.00056766560886498 | 0.0003101171214319 | RFC3/RFC4/TOPBP1 | 3 |
| reactome | B_14_24 | R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3/24 | 41/11146 | 8.86229009620436e-05 | 0.00056766560886498 | 0.0003101171214319 | RFC3/RFC4/TOPBP1 | 3 |
| MeSH_gene2pubmed | B_14_24 | D003302 | D003302 | 2/31 | 12/26076 | 8.96068323816953e-05 | 0.00290123253522621 | 0.00188290027129759 | CHAF1A/DHFR | 2 |
| GO | B_14_24 | GO:0040029 | epigenetic regulation of gene expression | 5/30 | 295/18986 | 9.07069094819734e-05 | 0.00249947928350327 | 0.00162317627494058 | H2AC20/HELLS/LMNB1/MIS18A/PHF19 | 5 |
| MeSH_gene2pubmed | B_14_24 | D011740 | Pyrimidine Dimers | 3/31 | 74/26076 | 9.31362632214536e-05 | 0.00295966347570397 | 0.00192082195883622 | DHFR/TTF2/UNG | 3 |
| reactome | B_14_24 | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3/24 | 43/11146 | 0.00010230848570247 | 0.00063808187135489 | 0.00034858569920786 | RFC3/RFC4/TOPBP1 | 3 |
| GO | B_14_24 | GO:0044839 | cell cycle G2/M phase transition | 4/30 | 158/18986 | 0.00010688930110863 | 0.00267252890067346 | 0.00173555569525908 | ATAD5/RRM1/SKP2/TOPBP1 | 4 |
| GO | B_14_24 | GO:0035561 | regulation of chromatin binding | 2/30 | 10/18986 | 0.00010776326212393 | 0.00267252890067346 | 0.00173555569525908 | DDX11/GMNN | 2 |