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Selected Module: B_14_23


Module Info

Module_Name B_14_23
Cell_Type B
Name B_14_23: ras GTPase-Activating Proteins
Meta_Module B_6
Gene_Number 31

Genes:

AAGAB, ANKRD36C, ARHGAP26, CASP8, CBL, CRACR2A, DGKZ, DIAPH1, DIP2A, GAK, GFOD1, GTDC1, IL2RG, LNPK, MINDY2, MTMR12, NPLOC4, NUP93, PPP2R5C, PREX1, PRORP, RASA3, RASGRP1, RFWD3, SACM1L, SASH3, SOAT1, TGFB1, TMEM127, ZBTB7A, ZNFX1


UMAP Visualizations


UMAP for B_14_23

UMAP for B_14_23


Word Cloud

Enriched TF

Wordcloud for B_14_23
TF p.adjust Genes
ELK1 0.0347907857235609 DGKZ/SASH3/TMEM127/ZNFX1
ETS2 0.0347907857235609 DGKZ/RASA3/ZBTB7A/ZNFX1


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
GO B_14_23 GO:0045582 positive regulation of T cell differentiation 4/29 122/18986 3.40358997493822e-05 0.00554359717168063 0.00400369662841417 IL2RG/RASGRP1/SASH3/TGFB1 4
GO B_14_23 GO:0045621 positive regulation of lymphocyte differentiation 4/29 137/18986 5.35667598867264e-05 0.00775527645915606 0.0056010155951735 IL2RG/RASGRP1/SASH3/TGFB1 4
GO B_14_23 GO:0051056 regulation of small GTPase mediated signal transduction 5/29 300/18986 8.28752220664696e-05 0.010798641435261 0.00779899458183409 ARHGAP26/CBL/PREX1/RASA3/RASGRP1 5
GO B_14_23 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/30 10/18737 0.00011063497711717 0.0154888967964047 0.0114128713236666 MINDY2/NPLOC4 2
GO B_14_23 GO:0033089 positive regulation of T cell differentiation in thymus 2/29 11/18986 0.00012284797601274 0.0133392427287174 0.00963386759257855 IL2RG/RASGRP1 2
GO B_14_23 GO:0034776 response to histamine 2/29 11/18986 0.00012284797601274 0.0133392427287174 0.00963386759257855 CRACR2A/DIAPH1 2
GO B_14_23 GO:1902105 regulation of leukocyte differentiation 5/29 337/18986 0.00014307394834519 0.0143404118995224 0.0103569319692798 CASP8/IL2RG/RASGRP1/SASH3/TGFB1 5
reactome B_14_23 R-HSA-9013406 RHOQ GTPase cycle 3/20 59/11146 0.00015065366098385 0.0269702976783179 0.0194791239474598 ARHGAP26/GFOD1/PREX1 3
onek1k B_14_23 NK NK 6/20 287/6471 0.00016528358867429 0.00066113435469718 0.00034796544984062 DGKZ/DIP2A/GFOD1/IL2RG/PPP2R5C/TGFB1 6
GO B_14_23 GO:0045580 regulation of T cell differentiation 4/29 191/18986 0.00019359166863255 0.0180178531591587 0.0130128535156019 IL2RG/RASGRP1/SASH3/TGFB1 4