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Selected Module: B_14_11


Module Info

Module_Name B_14_11
Cell_Type B
Name B_14_11: negative regulation of double-strand break repair
Meta_Module B_21
Gene_Number 41

Genes:

ALDH9A1, ALKBH6, AP3M1, APBA3, ARL2BP, CAMKMT, CHAMP1, CNPPD1, E4F1, EIF2B5, FAM219B, FPGS, HLA-DQA2, HSF1, IFT43, IKBKG, KCNAB2, LZIC, MAGEF1, MAP3K11, MIB2, MUS81, NAA60, NCOA5, PARP8, PEF1, PLPBP, PYGO2, RAB7A, RNF40, RSAD1, RTL8C, SKP1, STK25, TBC1D17, TFIP11, TP53I13, USP21, ZBTB17, ZFAND2B, ZNF32


UMAP Visualizations


UMAP for B_14_11

UMAP for B_14_11


Word Cloud

Enriched TF

Wordcloud for B_14_11
TF p.adjust Genes
HOXA7 0.00680262358855301 AP3M1/FPGS/MAP3K11/TBC1D17
RYTGCNNRGNAAC 0.0297963754184024 HSF1/NAA60/NCOA5
PAX3 0.0297963754184024 E4F1/PLPBP/RAB7A
RFX1 0.036584946984678 HSF1/NAA60/NCOA5/TFIP11
NRF2 0.036584946984678 CNPPD1/KCNAB2/LZIC/TBC1D17


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
GO B_14_11 GO:2000780 negative regulation of double-strand break repair 3/37 39/18986 5.93253934498563e-05 0.0219117658097928 0.0187425962003367 HSF1/MAGEF1/TFIP11 3
GO B_14_11 GO:0045738 negative regulation of DNA repair 3/37 41/18986 6.90134356213947e-05 0.0219117658097928 0.0187425962003367 HSF1/MAGEF1/TFIP11 3
reactome B_14_11 R-HSA-5357905 Regulation of TNFR1 signaling 3/24 48/11146 0.00014237659891045 0.0278247345816477 0.0200267995189547 IKBKG/MIB2/USP21 3
reactome B_14_11 R-HSA-75893 TNF signaling 3/24 57/11146 0.00023781824428758 0.0278247345816477 0.0200267995189547 IKBKG/MIB2/USP21 3
reactome B_14_11 R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 2/24 16/11146 0.00052350274151896 0.0408332138384791 0.029389627594047 IKBKG/SKP1 2