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Selected Module: B_12_15
Module Info
| Module_Name | B_12_15 |
| Cell_Type | B |
| Name | B_12_15: response to virus |
| Meta_Module | B_20 |
| Gene_Number | 30 |
Genes:
CHMP5, DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, HERC5, IFI44, IFI44L, IFIT2, IFIT3, IFITM1, IRF7, IRF9, ISG15, LY6E, MX1, MX2, NMI, OAS1, OAS2, OAS3, PARP9, PLSCR1, SAMD9L, STAT1, TNFSF10, TRIM22, UBE2L6, XAF1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| ISRE | 4.33682855335823e-12 | DDX60/DTX3L/EPSTI1/IFI44/IFIT2/IFIT3/IRF9/ISG15/PARP9/XAF1 |
| STTTCRNTTT | 6.57893968504148e-10 | DTX3L/EPSTI1/IFI44/IFIT2/IFIT3/ISG15/PARP9/XAF1 |
| IRF | 2.97425446129766e-09 | DDX60/DTX3L/IFI44/IFIT2/IRF9/ISG15/PARP9/UBE2L6 |
| IRF7 | 1.3940631900746e-07 | DDX60/DTX3L/EPSTI1/IFIT2/ISG15/PARP9/XAF1 |
| ICSBP | 8.0670788913588e-05 | DTX3L/IFI44/IFIT3/ISG15/PARP9 |
| IRF1 | 8.0670788913588e-05 | DTX3L/IRF9/ISG15/PARP9/XAF1 |
| IRF2 | 0.0036613358814046 | DTX3L/PARP9/XAF1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| MeSH_gene2pubmed | B_12_15 | D047310 | D047310 | 2/30 | 81/26076 | 0.00391820046294489 | 0.0314000231544334 | 0.0203786522615884 | STAT1/TNFSF10 | 2 |
| MeSH_gene2pubmed | B_12_15 | D007140 | Immunoglobulin Fab Fragments | 3/30 | 279/26076 | 0.00397318728301762 | 0.0317305060526113 | 0.0205931360543947 | IRF9/STAT1/TNFSF10 | 3 |
| GO | B_12_15 | GO:0034142 | toll-like receptor 4 signaling pathway | 2/28 | 64/18986 | 0.00399602956492392 | 0.0248885974069572 | 0.0153410817644438 | NMI/OAS1 | 2 |
| GO | B_12_15 | GO:0045637 | regulation of myeloid cell differentiation | 3/28 | 219/18986 | 0.0040089015957515 | 0.0248885974069572 | 0.0153410817644438 | IRF7/ISG15/STAT1 | 3 |
| GO | B_12_15 | GO:0051098 | regulation of binding | 3/28 | 219/18986 | 0.0040089015957515 | 0.0248885974069572 | 0.0153410817644438 | DTX3L/IFIT2/PARP9 | 3 |
| GO | B_12_15 | GO:0030099 | myeloid cell differentiation | 4/28 | 451/18986 | 0.00409362271326393 | 0.025152568423766 | 0.0155037908511027 | CHMP5/IRF7/ISG15/STAT1 | 4 |
| MeSH_gene2pubmed | B_12_15 | D050503 | Indoleamine-Pyrrole 2,3,-Dioxygenase | 2/30 | 84/26076 | 0.00420669040071041 | 0.0334419230117954 | 0.0217038476903151 | IRF9/STAT1 | 2 |
| MeSH_gene2pubmed | B_12_15 | D050378 | T-Lymphocytes, Regulatory | 3/30 | 285/26076 | 0.00421646429654786 | 0.0334419230117954 | 0.0217038476903151 | IRF7/STAT1/TNFSF10 | 3 |
| GO | B_12_15 | GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction | 2/28 | 66/18986 | 0.00424400417504389 | 0.0258104743706751 | 0.0159093174768026 | EIF2AK2/NMI | 2 |
| MeSH_gene2pubmed | B_12_15 | D005095 | Exoribonucleases | 3/30 | 287/26076 | 0.00429953172639631 | 0.0336810576009963 | 0.0218590463222739 | IRF9/NMI/STAT1 | 3 |