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Selected Module: B_12_15


Module Info

Module_Name B_12_15
Cell_Type B
Name B_12_15: response to virus
Meta_Module B_20
Gene_Number 30

Genes:

CHMP5, DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, HERC5, IFI44, IFI44L, IFIT2, IFIT3, IFITM1, IRF7, IRF9, ISG15, LY6E, MX1, MX2, NMI, OAS1, OAS2, OAS3, PARP9, PLSCR1, SAMD9L, STAT1, TNFSF10, TRIM22, UBE2L6, XAF1


UMAP Visualizations


UMAP for B_12_15

UMAP for B_12_15


Word Cloud

Enriched TF

Wordcloud for B_12_15
TF p.adjust Genes
ISRE 4.33682855335823e-12 DDX60/DTX3L/EPSTI1/IFI44/IFIT2/IFIT3/IRF9/ISG15/PARP9/XAF1
STTTCRNTTT 6.57893968504148e-10 DTX3L/EPSTI1/IFI44/IFIT2/IFIT3/ISG15/PARP9/XAF1
IRF 2.97425446129766e-09 DDX60/DTX3L/IFI44/IFIT2/IRF9/ISG15/PARP9/UBE2L6
IRF7 1.3940631900746e-07 DDX60/DTX3L/EPSTI1/IFIT2/ISG15/PARP9/XAF1
ICSBP 8.0670788913588e-05 DTX3L/IFI44/IFIT3/ISG15/PARP9
IRF1 8.0670788913588e-05 DTX3L/IRF9/ISG15/PARP9/XAF1
IRF2 0.0036613358814046 DTX3L/PARP9/XAF1


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
MeSH_gene2pubmed B_12_15 D018354 Alphavirus Infections 2/30 39/26076 0.00092337222123842 0.0124548568787151 0.00808321688334012 ISG15/UBE2L6 2
MeSH_gene2pubmed B_12_15 D018911 Trinucleotide Repeats 4/30 383/26076 0.00092817824226126 0.0124548568787151 0.00808321688334012 EIF2AK2/IRF9/MX1/OAS1 4
GO B_12_15 GO:0007259 cell surface receptor signaling pathway via JAK-STAT 3/28 132/18986 0.00094759994731438 0.00754784677831877 0.00465241703573517 NMI/PARP9/STAT1 3
GO B_12_15 GO:1903901 negative regulation of viral life cycle 2/28 31/18986 0.00094981293351326 0.00754784677831877 0.00465241703573517 IFITM1/LY6E 2
MeSH_gene2pubmed B_12_15 D036541 ADP-ribosyl Cyclase 3/30 169/26076 0.00095466999983097 0.0127362910960109 0.00826586802409172 EIF2AK2/STAT1/TNFSF10 3
MeSH_gene2pubmed B_12_15 D049294 Phospholipid Transfer Proteins 3/30 170/26076 0.00097106778664654 0.012880600296438 0.00835952486629176 PLSCR1/STAT1/TNFSF10 3
GO B_12_15 GO:0032682 negative regulation of chemokine production 2/28 32/18986 0.00101221077419487 0.0079378634397387 0.00489281939326882 OAS1/OAS3 2
MeSH_gene2pubmed B_12_15 D019694 Hepatitis B, Chronic 3/30 174/26076 0.00103844573263586 0.0136956157195633 0.00888847084235088 EIF2AK2/MX1/TNFSF10 3
GO B_12_15 GO:0005164 tumor necrosis factor receptor binding 2/30 30/18737 0.00104839168337673 0.0184516936274304 0.0128014142391264 STAT1/TNFSF10 2
MeSH_gene2pubmed B_12_15 D000098 D000098 3/30 175/26076 0.00105574071299188 0.0138445998044616 0.00898516169011626 PLSCR1/STAT1/TNFSF10 3