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Selected Module: B_12_15
Module Info
| Module_Name | B_12_15 |
| Cell_Type | B |
| Name | B_12_15: response to virus |
| Meta_Module | B_20 |
| Gene_Number | 30 |
Genes:
CHMP5, DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, HERC5, IFI44, IFI44L, IFIT2, IFIT3, IFITM1, IRF7, IRF9, ISG15, LY6E, MX1, MX2, NMI, OAS1, OAS2, OAS3, PARP9, PLSCR1, SAMD9L, STAT1, TNFSF10, TRIM22, UBE2L6, XAF1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| ISRE | 4.33682855335823e-12 | DDX60/DTX3L/EPSTI1/IFI44/IFIT2/IFIT3/IRF9/ISG15/PARP9/XAF1 |
| STTTCRNTTT | 6.57893968504148e-10 | DTX3L/EPSTI1/IFI44/IFIT2/IFIT3/ISG15/PARP9/XAF1 |
| IRF | 2.97425446129766e-09 | DDX60/DTX3L/IFI44/IFIT2/IRF9/ISG15/PARP9/UBE2L6 |
| IRF7 | 1.3940631900746e-07 | DDX60/DTX3L/EPSTI1/IFIT2/ISG15/PARP9/XAF1 |
| ICSBP | 8.0670788913588e-05 | DTX3L/IFI44/IFIT3/ISG15/PARP9 |
| IRF1 | 8.0670788913588e-05 | DTX3L/IRF9/ISG15/PARP9/XAF1 |
| IRF2 | 0.0036613358814046 | DTX3L/PARP9/XAF1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| MeSH_gene2pubmed | B_12_15 | D050862 | Oxidoreductases Acting on Sulfur Group Donors | 2/30 | 28/26076 | 0.00047475026111922 | 0.00755671450112539 | 0.00490431667203385 | STAT1/TNFSF10 | 2 |
| MeSH_gene2pubmed | B_12_15 | D020086 | Short Interspersed Nucleotide Elements | 3/30 | 134/26076 | 0.00048667878043603 | 0.00764118792684603 | 0.00495914002549572 | OAS1/OAS2/OAS3 | 3 |
| MeSH_gene2pubmed | B_12_15 | D048008 | TNF Receptor-Associated Factor 3 | 3/30 | 134/26076 | 0.00048667878043603 | 0.00764118792684603 | 0.00495914002549572 | IRF7/STAT1/TNFSF10 | 3 |
| GO | B_12_15 | GO:0032602 | chemokine production | 3/28 | 105/18986 | 0.00048691196546259 | 0.00460634176850332 | 0.00283930285624807 | EIF2AK2/OAS1/OAS3 | 3 |
| GO | B_12_15 | GO:0032642 | regulation of chemokine production | 3/28 | 105/18986 | 0.00048691196546259 | 0.00460634176850332 | 0.00283930285624807 | EIF2AK2/OAS1/OAS3 | 3 |
| MeSH_gene2pubmed | B_12_15 | D010767 | Phosphorylcholine | 3/30 | 136/26076 | 0.00050817888370281 | 0.0079248436728791 | 0.00514323294103209 | IRF9/PLSCR1/STAT1 | 3 |
| MeSH_gene2pubmed | B_12_15 | D015458 | Leukemia, T-Cell | 4/30 | 329/26076 | 0.00052625163369707 | 0.00815160248706604 | 0.00529039968033156 | IRF7/IRF9/STAT1/TNFSF10 | 4 |
| GO | B_12_15 | GO:0032760 | positive regulation of tumor necrosis factor production | 3/28 | 108/18986 | 0.00052871274435284 | 0.00484788916360452 | 0.0029881902474355 | OAS1/OAS2/OAS3 | 3 |
| GO | B_12_15 | GO:0060761 | negative regulation of response to cytokine stimulus | 3/28 | 108/18986 | 0.00052871274435284 | 0.00484788916360452 | 0.0029881902474355 | ISG15/OAS1/OAS3 | 3 |
| GO | B_12_15 | GO:1903557 | positive regulation of tumor necrosis factor superfamily cytokine production | 3/28 | 112/18986 | 0.00058793315866433 | 0.00530921458430213 | 0.00327254660883335 | OAS1/OAS2/OAS3 | 3 |