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Selected Module: B_12_15
Module Info
| Module_Name | B_12_15 |
| Cell_Type | B |
| Name | B_12_15: response to virus |
| Meta_Module | B_20 |
| Gene_Number | 30 |
Genes:
CHMP5, DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, HERC5, IFI44, IFI44L, IFIT2, IFIT3, IFITM1, IRF7, IRF9, ISG15, LY6E, MX1, MX2, NMI, OAS1, OAS2, OAS3, PARP9, PLSCR1, SAMD9L, STAT1, TNFSF10, TRIM22, UBE2L6, XAF1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| ISRE | 4.33682855335823e-12 | DDX60/DTX3L/EPSTI1/IFI44/IFIT2/IFIT3/IRF9/ISG15/PARP9/XAF1 |
| STTTCRNTTT | 6.57893968504148e-10 | DTX3L/EPSTI1/IFI44/IFIT2/IFIT3/ISG15/PARP9/XAF1 |
| IRF | 2.97425446129766e-09 | DDX60/DTX3L/IFI44/IFIT2/IRF9/ISG15/PARP9/UBE2L6 |
| IRF7 | 1.3940631900746e-07 | DDX60/DTX3L/EPSTI1/IFIT2/ISG15/PARP9/XAF1 |
| ICSBP | 8.0670788913588e-05 | DTX3L/IFI44/IFIT3/ISG15/PARP9 |
| IRF1 | 8.0670788913588e-05 | DTX3L/IRF9/ISG15/PARP9/XAF1 |
| IRF2 | 0.0036613358814046 | DTX3L/PARP9/XAF1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_12_15 | GO:0032069 | regulation of nuclease activity | 2/28 | 19/18986 | 0.00035312929137243 | 0.00375830460103522 | 0.00231658125355226 | OAS1/OAS3 | 2 |
| MeSH_gene2pubmed | B_12_15 | D019288 | Herpesvirus 8, Human | 4/30 | 297/26076 | 0.00035781464762539 | 0.00585699437389646 | 0.00380119629392259 | IRF7/STAT1/TNFSF10/TRIM22 | 4 |
| MeSH_gene2pubmed | B_12_15 | D016313 | Genes, abl | 3/30 | 124/26076 | 0.00038793917643838 | 0.0063053776001394 | 0.00409219753945013 | PLSCR1/STAT1/TNFSF10 | 3 |
| GO | B_12_15 | GO:0071605 | monocyte chemotactic protein-1 production | 2/28 | 20/18986 | 0.00039200808692174 | 0.00402822103112693 | 0.00248295503331561 | OAS1/OAS3 | 2 |
| GO | B_12_15 | GO:0071637 | regulation of monocyte chemotactic protein-1 production | 2/28 | 20/18986 | 0.00039200808692174 | 0.00402822103112693 | 0.00248295503331561 | OAS1/OAS3 | 2 |
| MeSH_gene2pubmed | B_12_15 | D015269 | Mycobacterium avium Complex | 2/30 | 26/26076 | 0.00040876894815341 | 0.00659747365271379 | 0.0042817682239404 | IRF9/STAT1 | 2 |
| GO | B_12_15 | GO:0072567 | chemokine (C-X-C motif) ligand 2 production | 2/28 | 21/18986 | 0.00043287703177619 | 0.00429991184897686 | 0.00265042252789284 | OAS1/OAS3 | 2 |
| GO | B_12_15 | GO:2000341 | regulation of chemokine (C-X-C motif) ligand 2 production | 2/28 | 21/18986 | 0.00043287703177619 | 0.00429991184897686 | 0.00265042252789284 | OAS1/OAS3 | 2 |
| GO | B_12_15 | GO:0001960 | negative regulation of cytokine-mediated signaling pathway | 3/28 | 103/18986 | 0.00046026245164033 | 0.00449699051110883 | 0.00277189983817905 | ISG15/OAS1/OAS3 | 3 |
| MeSH_gene2pubmed | B_12_15 | D002692 | D002692 | 3/30 | 132/26076 | 0.00046577218719158 | 0.00746529311137624 | 0.00484498408167855 | IRF9/STAT1/TNFSF10 | 3 |