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Selected Module: B_12_1
Module Info
| Module_Name | B_12_1 |
| Cell_Type | B |
| Name | B_12_1: HALLMARK_MYC_TARGETS_V1 |
| Meta_Module | B_3 |
| Gene_Number | 129 |
Genes:
AASDHPPT, ABCE1, ABCF1, ACAA1, AK2, APEH, ATP1A1, ATP5PB, ATP5PO, BMS1, BUD31, C19orf53, CD164, CDC37, CHMP4B, CKS2, CLTB, COA5, COPS5, COQ9, DBI, DCAF13, DCTD, DCXR, DDT, EBP, ECI1, EIF4G2, EIF4H, ETF1, EXOSC5, FARSB, FIBP, FRG1, FXN, GAR1, GET3, GOT2, GRPEL1, GSTO1, GTF2A2, GTF3A, HCFC1R1, HEBP2, HNRNPA3, HTRA2, INO80C, IPO5, ITGAE, ITGB1BP1, KGD4, KHSRP, LSM2, MAD2L2, MALSU1, MCRIP2, MDH1, ME2, MEA1, MED29, MLST8, MPV17, MRPL11, MRPL35, MRPL46, MRPL49, MRPL9, MRPS21, MRPS35, MVD, MZT1, NARS1, NDUFS1, NFU1, NIPA2, NME2, NUBP2, NUTF2, OLA1, PCMT1, PFDN4, PGD, PHAX, PPIA, PPP2CA, PRELID3B, PRPF38A, PSMA6, PSMB8, PSME1, PSME3, PSMG3, PTPA, QDPR, RAB10, RAP1A, RBBP4, RBM17, RBM3, RRP36, RTRAF, RWDD4, SDHAF3, SDHC, SF3B2, SFT2D1, SLC39A3, SMARCA4, SMIM20, SNRNP27, SNRPA1, SNRPD2, SSBP1, SSNA1, SYAP1, TDG, TFDP1, THOC6, TMEM106C, TPD52L2, TRAPPC3, TUBA1C, TXN2, UBB, UBE2D3, UROS, VTI1B, ZDHHC3, ZNF330
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| NR1I2 | 0.00225913858449317 | AK2/BUD31/GTF2A2/MLST8/MRPL11/MRPS21/PPIA/PTPA/RAP1A/RBM17 |
| ELF5 | 0.0190351123169518 | BMS1/C19orf53/FIBP/FRG1/INO80C/RBM3/RTRAF/SF3B2/SSBP1/TUBA1C |
| DMRT1 | 0.0214366259979039 | ATP5PB/MALSU1/MRPL11/MRPL46/PPIA/RBBP4/SNRPA1/TPD52L2/TXN2 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| KEGG | B_12_1 | hsa03050 | Proteasome | 4/80 | 46/8541 | 0.00086385909235762 | 0.0426170485563094 | 0.0406165327634812 | PSMA6/PSMB8/PSME1/PSME3 | 4 |
| reactome | B_12_1 | R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 3/107 | 20/11146 | 0.00087066115942235 | 0.00823170550726587 | 0.00614164262832445 | FXN/SDHAF3/SDHC | 3 |
| GO | B_12_1 | GO:0016226 | iron-sulfur cluster assembly | 3/124 | 29/18986 | 0.00087761472047499 | 0.0449894681369488 | 0.04245370538291 | FXN/NFU1/NUBP2 | 3 |
| GO | B_12_1 | GO:0031163 | metallo-sulfur cluster assembly | 3/124 | 29/18986 | 0.00087761472047499 | 0.0449894681369488 | 0.04245370538291 | FXN/NFU1/NUBP2 | 3 |
| MeSH_gene2pubmed | B_12_1 | D006790 | Host-Parasite Interactions | 5/128 | 150/26076 | 0.00088340484725726 | 0.0416418767655408 | 0.0384625812807656 | PPIA/PSMA6/PSMB8/PSME1/PSME3 | 5 |
| GO | B_12_1 | GO:0090079 | translation regulator activity, nucleic acid binding | 5/126 | 110/18737 | 0.00088472495533479 | 0.025496164621921 | 0.022858922290947 | ABCF1/COPS5/EIF4G2/EIF4H/ETF1 | 5 |
| reactome | B_12_1 | R-HSA-5619084 | ABC transporter disorders | 5/107 | 78/11146 | 0.00089864469618759 | 0.00838735049775084 | 0.00625776873458565 | PSMA6/PSMB8/PSME1/PSME3/UBB | 5 |
| GO | B_12_1 | GO:0071007 | U2-type catalytic step 2 spliceosome | 3/127 | 30/19960 | 0.00090078175698707 | 0.0131685713997634 | 0.0115589037488065 | BUD31/SNRPA1/SNRPD2 | 3 |
| GO | B_12_1 | GO:0009260 | ribonucleotide biosynthetic process | 6/124 | 171/18986 | 0.00090885718124814 | 0.0449894681369488 | 0.04245370538291 | AK2/ATP5PB/ATP5PO/NDUFS1/NME2/SDHC | 6 |
| GO | B_12_1 | GO:0097250 | mitochondrial respirasome assembly | 5/124 | 114/18986 | 0.00091197954266608 | 0.0449894681369488 | 0.04245370538291 | COA5/FXN/NDUFS1/SDHAF3/SMIM20 | 5 |