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Selected Module: B_12_1
Module Info
| Module_Name | B_12_1 |
| Cell_Type | B |
| Name | B_12_1: HALLMARK_MYC_TARGETS_V1 |
| Meta_Module | B_3 |
| Gene_Number | 129 |
Genes:
AASDHPPT, ABCE1, ABCF1, ACAA1, AK2, APEH, ATP1A1, ATP5PB, ATP5PO, BMS1, BUD31, C19orf53, CD164, CDC37, CHMP4B, CKS2, CLTB, COA5, COPS5, COQ9, DBI, DCAF13, DCTD, DCXR, DDT, EBP, ECI1, EIF4G2, EIF4H, ETF1, EXOSC5, FARSB, FIBP, FRG1, FXN, GAR1, GET3, GOT2, GRPEL1, GSTO1, GTF2A2, GTF3A, HCFC1R1, HEBP2, HNRNPA3, HTRA2, INO80C, IPO5, ITGAE, ITGB1BP1, KGD4, KHSRP, LSM2, MAD2L2, MALSU1, MCRIP2, MDH1, ME2, MEA1, MED29, MLST8, MPV17, MRPL11, MRPL35, MRPL46, MRPL49, MRPL9, MRPS21, MRPS35, MVD, MZT1, NARS1, NDUFS1, NFU1, NIPA2, NME2, NUBP2, NUTF2, OLA1, PCMT1, PFDN4, PGD, PHAX, PPIA, PPP2CA, PRELID3B, PRPF38A, PSMA6, PSMB8, PSME1, PSME3, PSMG3, PTPA, QDPR, RAB10, RAP1A, RBBP4, RBM17, RBM3, RRP36, RTRAF, RWDD4, SDHAF3, SDHC, SF3B2, SFT2D1, SLC39A3, SMARCA4, SMIM20, SNRNP27, SNRPA1, SNRPD2, SSBP1, SSNA1, SYAP1, TDG, TFDP1, THOC6, TMEM106C, TPD52L2, TRAPPC3, TUBA1C, TXN2, UBB, UBE2D3, UROS, VTI1B, ZDHHC3, ZNF330
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| NR1I2 | 0.00225913858449317 | AK2/BUD31/GTF2A2/MLST8/MRPL11/MRPS21/PPIA/PTPA/RAP1A/RBM17 |
| ELF5 | 0.0190351123169518 | BMS1/C19orf53/FIBP/FRG1/INO80C/RBM3/RTRAF/SF3B2/SSBP1/TUBA1C |
| DMRT1 | 0.0214366259979039 | ATP5PB/MALSU1/MRPL11/MRPL46/PPIA/RBBP4/SNRPA1/TPD52L2/TXN2 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_12_1 | R-HSA-6807070 | PTEN Regulation | 7/107 | 140/11146 | 0.00038914180716328 | 0.00515082246572499 | 0.00384300808605277 | MLST8/PSMA6/PSMB8/PSME1/PSME3/RBBP4/UBB | 7 |
| reactome | B_12_1 | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 10/107 | 285/11146 | 0.00040281798242048 | 0.00522955328324746 | 0.00390174883481158 | BUD31/HNRNPA3/LSM2/PRPF38A/RBM17/SF3B2/SNRNP27/SNRPA1/SNRPD2/THOC6 | 10 |
| GO | B_12_1 | GO:0031970 | organelle envelope lumen | 5/127 | 98/19960 | 0.0004078497598823 | 0.0073652868402275 | 0.0064649869058743 | AK2/HTRA2/NDUFS1/PRELID3B/SDHAF3 | 5 |
| GO | B_12_1 | GO:1905369 | endopeptidase complex | 5/127 | 98/19960 | 0.0004078497598823 | 0.0073652868402275 | 0.0064649869058743 | HTRA2/PSMA6/PSMB8/PSME1/PSME3 | 5 |
| reactome | B_12_1 | R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5/107 | 66/11146 | 0.00041664023410488 | 0.00522955328324746 | 0.00390174883481158 | PSMA6/PSMB8/PSME1/PSME3/UBB | 5 |
| reactome | B_12_1 | R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5/107 | 66/11146 | 0.00041664023410488 | 0.00522955328324746 | 0.00390174883481158 | PSMA6/PSMB8/PSME1/PSME3/UBB | 5 |
| reactome | B_12_1 | R-HSA-5689603 | UCH proteinases | 6/107 | 102/11146 | 0.00043414908793412 | 0.00533275247970956 | 0.00397874534345016 | INO80C/PSMA6/PSMB8/PSME1/PSME3/UBB | 6 |
| GO | B_12_1 | GO:0006119 | oxidative phosphorylation | 6/124 | 149/18986 | 0.00044088925827859 | 0.0356118278164116 | 0.0336046214563538 | ATP5PB/ATP5PO/COQ9/FXN/NDUFS1/SDHC | 6 |
| reactome | B_12_1 | R-HSA-1169091 | Activation of NF-kappaB in B cells | 5/107 | 67/11146 | 0.00044683777645918 | 0.00533275247970956 | 0.00397874534345016 | PSMA6/PSMB8/PSME1/PSME3/UBB | 5 |
| reactome | B_12_1 | R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 5/107 | 67/11146 | 0.00044683777645918 | 0.00533275247970956 | 0.00397874534345016 | PSMA6/PSMB8/PSME1/PSME3/UBB | 5 |