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Selected Module: B_11_7
Module Info
| Module_Name | B_11_7 |
| Cell_Type | B |
| Name | B_11_7: NK |
| Meta_Module | B_14 |
| Gene_Number | 35 |
Genes:
ABHD17A, APMAP, ARL4C, CCL4, CCL5, CD2, CD247, CD7, CEP78, CMC1, CST7, CTSW, DOK2, EFHD2, GNG2, GNLY, GZMA, GZMB, GZMH, GZMM, HCST, HOPX, ID2, MT2A, NKG7, PAXX, PRF1, PTPN4, PYHIN1, RASAL3, RNF166, RUNX3, SIGIRR, SYNE1, TSEN54
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| TTCYNRGAA | 0.00813456338594291 | CCL5/CD247/GZMB/NKG7/SIGIRR |
| PEA3 | 0.0222091387733846 | CD247/CTSW/PRF1/RUNX3 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| onek1k | B_11_7 | NK_CD56bright | NK_CD56bright | 12/33 | 222/6471 | 3.71396353690937e-10 | 4.64245442113672e-10 | 9.77358825502466e-11 | APMAP/CD2/CD7/CEP78/CMC1/CTSW/GNLY/HCST/HOPX/ID2/NKG7/RUNX3 | 12 |
| GO | B_11_7 | GO:0001906 | cell killing | 9/33 | 264/18986 | 4.88652333888563e-10 | 2.64016227867602e-07 | 1.90274853217979e-07 | CD2/GNLY/GZMA/GZMB/GZMH/GZMM/HCST/NKG7/PRF1 | 9 |
| GO | B_11_7 | GO:0140507 | granzyme-mediated programmed cell death signaling pathway | 4/33 | 10/18986 | 1.57609656964721e-09 | 2.64016227867602e-07 | 1.90274853217979e-07 | GZMA/GZMB/NKG7/PRF1 | 4 |
| GO | B_11_7 | GO:0031640 | killing of cells of another organism | 7/33 | 124/18986 | 1.58533728939087e-09 | 2.64016227867602e-07 | 1.90274853217979e-07 | GNLY/GZMA/GZMB/GZMH/GZMM/NKG7/PRF1 | 7 |
| GO | B_11_7 | GO:0141061 | disruption of cell in another organism | 7/33 | 124/18986 | 1.58533728939087e-09 | 2.64016227867602e-07 | 1.90274853217979e-07 | GNLY/GZMA/GZMB/GZMH/GZMM/NKG7/PRF1 | 7 |
| GO | B_11_7 | GO:0141060 | disruption of anatomical structure in another organism | 7/33 | 127/18986 | 1.87511525474149e-09 | 2.64016227867602e-07 | 1.90274853217979e-07 | GNLY/GZMA/GZMB/GZMH/GZMM/NKG7/PRF1 | 7 |
| MeSH_gene2pubmed | B_11_7 | D018949 | Antigens, CD1 | 7/35 | 181/26076 | 3.94369239732921e-09 | 1.17522033440411e-06 | 7.38923417604842e-07 | CCL4/CCL5/CD7/GNLY/GZMA/GZMB/PRF1 | 7 |
| MeSH_gene2pubmed | B_11_7 | D055654 | NK Cell Lectin-Like Receptor Subfamily C | 5/35 | 59/26076 | 1.53658344173894e-08 | 3.75322966097312e-06 | 2.35985474974643e-06 | GNLY/GZMA/GZMB/HCST/NKG7 | 5 |
| MeSH_gene2pubmed | B_11_7 | D007945 | Leukemia, Lymphoid | 7/35 | 222/26076 | 1.61932248076501e-08 | 3.75322966097312e-06 | 2.35985474974643e-06 | CCL4/CCL5/CTSW/GZMA/GZMB/GZMH/GZMM | 7 |
| MeSH_gene2pubmed | B_11_7 | D016827 | CD8 Antigens | 8/35 | 374/26076 | 2.78925289362639e-08 | 5.74257049580904e-06 | 3.61065894826566e-06 | CCL4/CD247/GNLY/GZMA/GZMB/NKG7/PRF1/RUNX3 | 8 |