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Selected Module: B_10_7
Module Info
| Module_Name | B_10_7 |
| Cell_Type | B |
| Name | B_10_7: HALLMARK_E2F_TARGETS |
| Meta_Module | B_9 |
| Gene_Number | 55 |
Genes:
BZW2, C19orf48P, C1QBP, CARHSP1, CCT2, CCT3, CCT4, CCT6A, DDX39A, DNAJC9, DTYMK, DUT, EIF4A3, ENO1, EXOSC8, H2AZ1, HMGA1, HMGB2, HMGN2, HNRNPAB, HSP90AA1, HSPA9, HSPE1, LSM4, MCM3, MCM5, MCM7, MRTO4, NASP, NHP2, NUDC, NUDT1, PA2G4, PCNA, PSMD2, RAD51C, RAN, RANBP1, SERBP1, SIVA1, SLBP, SLC25A5, SNRNP25, SNRPB, SNRPE, SNRPF, SNRPG, SRSF3, SSRP1, STMN1, TCP1, TUBA1B, VRK1, XRCC5, YBX1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| E2F | 3.75169733798822e-10 | H2AZ1/HMGA1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/SLBP/STMN1 |
| E2F | 3.75169733798822e-10 | DNAJC9/H2AZ1/HMGN2/MCM3/MCM7/NASP/RANBP1/SERBP1/SLBP/STMN1/TCP1 |
| E2F | 2.08944928636572e-09 | H2AZ1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1/TCP1 |
| E2F1 | 2.08944928636572e-09 | H2AZ1/HMGA1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1 |
| E2F | 2.08944928636572e-09 | H2AZ1/HMGA1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1 |
| E2F1 | 2.08944928636572e-09 | DNAJC9/H2AZ1/HMGA1/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1 |
| E2F1 | 2.80328444013542e-09 | DNAJC9/H2AZ1/HMGN2/MCM3/MCM7/NASP/PCNA/SERBP1/STMN1/TCP1 |
| E2F | 2.68835611224921e-08 | DNAJC9/H2AZ1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/STMN1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_10_7 | R-HSA-176187 | Activation of ATR in response to replication stress | 3/45 | 37/11146 | 0.00043410599780995 | 0.00535006310814433 | 0.00456953681905218 | MCM3/MCM5/MCM7 | 3 |
| MeSH_gene2pubmed | B_10_7 | D000266 | Adenylyl Imidodiphosphate | 3/54 | 71/26076 | 0.00043430733432521 | 0.00897148870325898 | 0.00636719066798672 | EIF4A3/HSP90AA1/PCNA | 3 |
| GO | B_10_7 | GO:0006364 | rRNA processing | 5/54 | 225/18986 | 0.0004408019128493 | 0.00458529815866074 | 0.00333879709732542 | EIF4A3/EXOSC8/MRTO4/NHP2/PA2G4 | 5 |
| GO | B_10_7 | GO:0034502 | protein localization to chromosome | 4/54 | 126/18986 | 0.00045246794871222 | 0.0046560411496516 | 0.00339030879510462 | CCT6A/TCP1/VRK1/XRCC5 | 4 |
| MeSH_gene2pubmed | B_10_7 | D015473 | Leukemia, Promyelocytic, Acute | 6/54 | 480/26076 | 0.00046099366247325 | 0.00947696586892127 | 0.0067259348629068 | C1QBP/HSP90AA1/HSPA9/PCNA/STMN1/XRCC5 | 6 |
| reactome | B_10_7 | R-HSA-69242 | S Phase | 5/45 | 162/11146 | 0.00046578981928797 | 0.00558947783145568 | 0.0047740230785748 | MCM3/MCM5/MCM7/PCNA/PSMD2 | 5 |
| GO | B_10_7 | GO:0006275 | regulation of DNA replication | 4/54 | 127/18986 | 0.00046620359026702 | 0.00474634931793133 | 0.00345606692896721 | MCM3/MCM5/MCM7/PCNA | 4 |
| MeSH_gene2pubmed | B_10_7 | D020460 | Melanosomes | 4/54 | 174/26076 | 0.00046693173051517 | 0.00955311042910473 | 0.00677997571934148 | CCT4/HSP90AA1/PCNA/RAN | 4 |
| reactome | B_10_7 | R-HSA-69052 | Switching of origins to a post-replicative state | 4/45 | 91/11146 | 0.00047966846138857 | 0.00560843124085097 | 0.00479021135529746 | MCM3/MCM5/MCM7/PSMD2 | 4 |
| MeSH_gene2pubmed | B_10_7 | D045325 | HCT116 Cells | 6/54 | 486/26076 | 0.00049217988338713 | 0.0100217199112541 | 0.00711255440503808 | HSP90AA1/PCNA/RAN/SSRP1/XRCC5/YBX1 | 6 |