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Selected Module: B_10_7
Module Info
| Module_Name | B_10_7 |
| Cell_Type | B |
| Name | B_10_7: HALLMARK_E2F_TARGETS |
| Meta_Module | B_9 |
| Gene_Number | 55 |
Genes:
BZW2, C19orf48P, C1QBP, CARHSP1, CCT2, CCT3, CCT4, CCT6A, DDX39A, DNAJC9, DTYMK, DUT, EIF4A3, ENO1, EXOSC8, H2AZ1, HMGA1, HMGB2, HMGN2, HNRNPAB, HSP90AA1, HSPA9, HSPE1, LSM4, MCM3, MCM5, MCM7, MRTO4, NASP, NHP2, NUDC, NUDT1, PA2G4, PCNA, PSMD2, RAD51C, RAN, RANBP1, SERBP1, SIVA1, SLBP, SLC25A5, SNRNP25, SNRPB, SNRPE, SNRPF, SNRPG, SRSF3, SSRP1, STMN1, TCP1, TUBA1B, VRK1, XRCC5, YBX1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| E2F | 3.75169733798822e-10 | H2AZ1/HMGA1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/SLBP/STMN1 |
| E2F | 3.75169733798822e-10 | DNAJC9/H2AZ1/HMGN2/MCM3/MCM7/NASP/RANBP1/SERBP1/SLBP/STMN1/TCP1 |
| E2F | 2.08944928636572e-09 | H2AZ1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1/TCP1 |
| E2F1 | 2.08944928636572e-09 | H2AZ1/HMGA1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1 |
| E2F | 2.08944928636572e-09 | H2AZ1/HMGA1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1 |
| E2F1 | 2.08944928636572e-09 | DNAJC9/H2AZ1/HMGA1/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1 |
| E2F1 | 2.80328444013542e-09 | DNAJC9/H2AZ1/HMGN2/MCM3/MCM7/NASP/PCNA/SERBP1/STMN1/TCP1 |
| E2F | 2.68835611224921e-08 | DNAJC9/H2AZ1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/STMN1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_10_7 | GO:0090685 | RNA localization to nucleus | 6/54 | 19/18986 | 1.04804893070985e-11 | 1.67163804448221e-09 | 1.21720770549109e-09 | CCT2/CCT3/CCT4/CCT6A/NHP2/TCP1 | 6 |
| GO | B_10_7 | GO:0006278 | RNA-templated DNA biosynthetic process | 8/54 | 69/18986 | 1.82401587892454e-11 | 2.49369028018684e-09 | 1.81578723586173e-09 | CCT2/CCT3/CCT4/CCT6A/HSP90AA1/NHP2/TCP1/XRCC5 | 8 |
| GO | B_10_7 | GO:0140662 | ATP-dependent protein folding chaperone | 7/54 | 40/18737 | 1.91098421819796e-11 | 3.13401411784466e-09 | 2.07190920499358e-09 | CCT2/CCT3/CCT4/CCT6A/HSP90AA1/HSPA9/TCP1 | 7 |
| GO | B_10_7 | GO:0000723 | telomere maintenance | 10/54 | 162/18986 | 2.67988628767324e-11 | 3.06005657660952e-09 | 2.22818836684321e-09 | CCT2/CCT3/CCT4/CCT6A/HSP90AA1/NHP2/PCNA/RAD51C/TCP1/XRCC5 | 10 |
| GO | B_10_7 | GO:0051084 | 'de novo' post-translational protein folding | 7/54 | 44/18986 | 3.5535619628335e-11 | 3.06005657660952e-09 | 2.22818836684321e-09 | CCT2/CCT3/CCT4/CCT6A/HSPA9/HSPE1/TCP1 | 7 |
| GO | B_10_7 | GO:0010833 | telomere maintenance via telomere lengthening | 8/54 | 75/18986 | 3.63296807961131e-11 | 3.06005657660952e-09 | 2.22818836684321e-09 | CCT2/CCT3/CCT4/CCT6A/HSP90AA1/NHP2/TCP1/XRCC5 | 8 |
| GO | B_10_7 | GO:1904869 | regulation of protein localization to Cajal body | 5/54 | 10/18986 | 3.83706153806836e-11 | 3.06005657660952e-09 | 2.22818836684321e-09 | CCT2/CCT3/CCT4/CCT6A/TCP1 | 5 |
| GO | B_10_7 | GO:1904871 | positive regulation of protein localization to Cajal body | 5/54 | 10/18986 | 3.83706153806836e-11 | 3.06005657660952e-09 | 2.22818836684321e-09 | CCT2/CCT3/CCT4/CCT6A/TCP1 | 5 |
| GO | B_10_7 | GO:0044183 | protein folding chaperone | 8/54 | 75/18737 | 4.0299628657542e-11 | 3.30456954991845e-09 | 2.18466407985623e-09 | CCT2/CCT3/CCT4/CCT6A/HSP90AA1/HSPA9/HSPE1/TCP1 | 8 |
| MeSH_gene2pubmed | B_10_7 | D017381 | Spliceosomes | 12/54 | 422/26076 | 5.13110968362121e-11 | 5.48515625179107e-08 | 3.89289189944209e-08 | C1QBP/EIF4A3/LSM4/SNRNP25/SNRPB/SNRPE/SNRPF/SNRPG/SRSF3/SSRP1/XRCC5/YBX1 | 12 |