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Selected Module: B_10_7
Module Info
| Module_Name | B_10_7 |
| Cell_Type | B |
| Name | B_10_7: HALLMARK_E2F_TARGETS |
| Meta_Module | B_9 |
| Gene_Number | 55 |
Genes:
BZW2, C19orf48P, C1QBP, CARHSP1, CCT2, CCT3, CCT4, CCT6A, DDX39A, DNAJC9, DTYMK, DUT, EIF4A3, ENO1, EXOSC8, H2AZ1, HMGA1, HMGB2, HMGN2, HNRNPAB, HSP90AA1, HSPA9, HSPE1, LSM4, MCM3, MCM5, MCM7, MRTO4, NASP, NHP2, NUDC, NUDT1, PA2G4, PCNA, PSMD2, RAD51C, RAN, RANBP1, SERBP1, SIVA1, SLBP, SLC25A5, SNRNP25, SNRPB, SNRPE, SNRPF, SNRPG, SRSF3, SSRP1, STMN1, TCP1, TUBA1B, VRK1, XRCC5, YBX1
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| E2F | 3.75169733798822e-10 | H2AZ1/HMGA1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/SLBP/STMN1 |
| E2F | 3.75169733798822e-10 | DNAJC9/H2AZ1/HMGN2/MCM3/MCM7/NASP/RANBP1/SERBP1/SLBP/STMN1/TCP1 |
| E2F | 2.08944928636572e-09 | H2AZ1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1/TCP1 |
| E2F1 | 2.08944928636572e-09 | H2AZ1/HMGA1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1 |
| E2F | 2.08944928636572e-09 | H2AZ1/HMGA1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1 |
| E2F1 | 2.08944928636572e-09 | DNAJC9/H2AZ1/HMGA1/MCM3/MCM7/NASP/PCNA/RANBP1/SERBP1/STMN1 |
| E2F1 | 2.80328444013542e-09 | DNAJC9/H2AZ1/HMGN2/MCM3/MCM7/NASP/PCNA/SERBP1/STMN1/TCP1 |
| E2F | 2.68835611224921e-08 | DNAJC9/H2AZ1/HMGN2/MCM3/MCM7/NASP/PCNA/RANBP1/STMN1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_10_7 | GO:0000727 | double-strand break repair via break-induced replication | 3/54 | 12/18986 | 4.69875773852763e-06 | 8.64752145340566e-05 | 6.29671583584067e-05 | MCM3/MCM5/MCM7 | 3 |
| GO | B_10_7 | GO:0015931 | nucleobase-containing compound transport | 7/54 | 239/18986 | 4.91021671049646e-06 | 8.866183758387e-05 | 6.4559353770579e-05 | DDX39A/EIF4A3/RAN/SLBP/SLC25A5/SRSF3/YBX1 | 7 |
| MeSH_gene2pubmed | B_10_7 | D004256 | DNA Polymerase I | 5/54 | 120/26076 | 5.01209379833547e-06 | 0.00029397854256141 | 0.00020864067209998 | MCM7/NHP2/PCNA/XRCC5/YBX1 | 5 |
| MeSH_gene2pubmed | B_10_7 | D051863 | Host Cell Factor C1 | 6/54 | 212/26076 | 5.01881047871452e-06 | 0.00029397854256141 | 0.00020864067209998 | HMGB2/HSP90AA1/HSPA9/PCNA/XRCC5/YBX1 | 6 |
| KEGG | B_10_7 | hsa03030 | DNA replication | 4/28 | 36/8541 | 5.06483343603873e-06 | 0.00017473675354333 | 0.00015727640669804 | MCM3/MCM5/MCM7/PCNA | 4 |
| MeSH_gene2pubmed | B_10_7 | D051721 | Rad52 DNA Repair and Recombination Protein | 4/54 | 55/26076 | 5.17873763844451e-06 | 0.00029760710058526 | 0.00021121591034102 | MCM3/PCNA/RAD51C/XRCC5 | 4 |
| GO | B_10_7 | GO:0004386 | helicase activity | 6/54 | 154/18737 | 5.21436715055826e-06 | 0.00012216517324165 | 8.0763882181579e-05 | DDX39A/EIF4A3/MCM3/MCM5/MCM7/XRCC5 | 6 |
| MeSH_gene2pubmed | B_10_7 | D036961 | Matrix Attachment Region Binding Proteins | 5/54 | 121/26076 | 5.21995616087348e-06 | 0.00029760710058526 | 0.00021121591034102 | PCNA/SRSF3/SSRP1/XRCC5/YBX1 | 5 |
| GO | B_10_7 | GO:0031261 | DNA replication preinitiation complex | 3/54 | 13/19960 | 5.25163115843414e-06 | 4.25382123833165e-05 | 2.26649344732421e-05 | MCM3/MCM5/MCM7 | 3 |
| MeSH_gene2pubmed | B_10_7 | D016325 | HIV Long Terminal Repeat | 8/54 | 474/26076 | 5.61673761969909e-06 | 0.00031601539555043 | 0.00022428053403867 | CCT4/ENO1/H2AZ1/HMGA1/SLBP/SNRPB/XRCC5/YBX1 | 8 |