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Selected Module: B_10_12
Module Info
| Module_Name | B_10_12 |
| Cell_Type | B |
| Name | B_10_12: actin filament organization |
| Meta_Module | B_13 |
| Gene_Number | 50 |
Genes:
ACTB, ACTR3, ANXA6, ARHGDIB, ARL6IP5, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, BBLN, CALM2, CAP1, CAPZB, CD53, CFL1, CNN2, CORO1A, CSK, DUS2, FDFT1, HCLS1, ILK, LCP1, MTMR14, MYL12A, MYO1G, PDLIM1, PFN1, PPP1CA, PPP1R18, PRR13, PTPN6, RAC2, RGS19, RHOA, RHOG, RPS6KA1, SHKBP1, SYTL1, TADA3, TBC1D10C, TBCB, TMSB4X, TPM3, TRAPPC1, TSC22D4, TWF2, UCP2, VASP
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| SRF | 3.9374041695952e-11 | ACTB/ACTR3/ANXA6/ARPC4/CAP1/CFL1/CNN2/LCP1/PFN1/TADA3/TPM3 |
| SRF | 3.9374041695952e-11 | ACTB/ACTR3/ANXA6/ARPC4/CFL1/CNN2/LCP1/PFN1/TADA3/TPM3/VASP |
| SRF | 5.15518863810196e-08 | ACTR3/ANXA6/CAP1/CFL1/CNN2/PFN1 |
| SRF | 5.15654404051782e-08 | ACTB/ACTR3/ANXA6/ARPC4/CFL1/CNN2/PFN1/TADA3/TPM3 |
| ELK1 | 1.02349670677999e-07 | ARHGDIB/ARPC4/LCP1/PPP1CA/SYTL1/TADA3/TBC1D10C/TRAPPC1/VASP |
| SRF | 4.72727443461202e-07 | ACTB/ANXA6/ARPC4/CFL1/PFN1/TADA3/TPM3/VASP |
| ETS | 8.25848206285004e-07 | ACTR3/ARPC1B/CALM2/CAP1/CORO1A/HCLS1/LCP1/TBC1D10C |
| NERF | 1.64933095087325e-05 | ACTR3/ARHGDIB/CALM2/CAP1/CORO1A/HCLS1/PTPN6 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_10_12 | R-HSA-4086400 | PCP/CE pathway | 3/43 | 92/11146 | 0.00529051465107575 | 0.0384444064644838 | 0.0289586065111515 | PFN1/RAC2/RHOA | 3 |
| reactome | B_10_12 | R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2/43 | 29/11146 | 0.00552509030246251 | 0.0392761854109835 | 0.0295851517340098 | CALM2/RPS6KA1 | 2 |
| reactome | B_10_12 | R-HSA-3928663 | EPHA-mediated growth cone collapse | 2/43 | 30/11146 | 0.00590531538622322 | 0.0410859176871275 | 0.0309483493925248 | MYL12A/RHOA | 2 |
| GO | B_10_12 | GO:0001772 | immunological synapse | 2/50 | 48/19960 | 0.00644521865473189 | 0.0325744834712125 | 0.0196198690200942 | CD53/CORO1A | 2 |
| reactome | B_10_12 | R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3/43 | 99/11146 | 0.00648561030716174 | 0.0438222872457459 | 0.0330095451971819 | ACTB/CALM2/RHOA | 3 |
| reactome | B_10_12 | R-HSA-5626467 | RHO GTPases activate IQGAPs | 2/43 | 32/11146 | 0.00670065554216299 | 0.0438222872457459 | 0.0330095451971819 | ACTB/CALM2 | 2 |
| reactome | B_10_12 | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 2/43 | 32/11146 | 0.00670065554216299 | 0.0438222872457459 | 0.0330095451971819 | CALM2/PTPN6 | 2 |
| GO | B_10_12 | GO:0043296 | apical junction complex | 3/50 | 154/19960 | 0.00677125268854245 | 0.0333216908620379 | 0.0200699179411092 | ACTB/RHOA/VASP | 3 |
| GO | B_10_12 | GO:0042581 | specific granule | 3/50 | 160/19960 | 0.00752037728134114 | 0.0360592449130973 | 0.0217187683968557 | CD53/CNN2/PTPN6 | 3 |
| GO | B_10_12 | GO:0030667 | secretory granule membrane | 4/50 | 320/19960 | 0.00836562489029806 | 0.0382588232624865 | 0.0230435918327388 | CD53/RHOA/RHOG/TBC1D10C | 4 |