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Selected Module: B_10_12
Module Info
| Module_Name | B_10_12 |
| Cell_Type | B |
| Name | B_10_12: actin filament organization |
| Meta_Module | B_13 |
| Gene_Number | 50 |
Genes:
ACTB, ACTR3, ANXA6, ARHGDIB, ARL6IP5, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, BBLN, CALM2, CAP1, CAPZB, CD53, CFL1, CNN2, CORO1A, CSK, DUS2, FDFT1, HCLS1, ILK, LCP1, MTMR14, MYL12A, MYO1G, PDLIM1, PFN1, PPP1CA, PPP1R18, PRR13, PTPN6, RAC2, RGS19, RHOA, RHOG, RPS6KA1, SHKBP1, SYTL1, TADA3, TBC1D10C, TBCB, TMSB4X, TPM3, TRAPPC1, TSC22D4, TWF2, UCP2, VASP
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| SRF | 3.9374041695952e-11 | ACTB/ACTR3/ANXA6/ARPC4/CAP1/CFL1/CNN2/LCP1/PFN1/TADA3/TPM3 |
| SRF | 3.9374041695952e-11 | ACTB/ACTR3/ANXA6/ARPC4/CFL1/CNN2/LCP1/PFN1/TADA3/TPM3/VASP |
| SRF | 5.15518863810196e-08 | ACTR3/ANXA6/CAP1/CFL1/CNN2/PFN1 |
| SRF | 5.15654404051782e-08 | ACTB/ACTR3/ANXA6/ARPC4/CFL1/CNN2/PFN1/TADA3/TPM3 |
| ELK1 | 1.02349670677999e-07 | ARHGDIB/ARPC4/LCP1/PPP1CA/SYTL1/TADA3/TBC1D10C/TRAPPC1/VASP |
| SRF | 4.72727443461202e-07 | ACTB/ANXA6/ARPC4/CFL1/PFN1/TADA3/TPM3/VASP |
| ETS | 8.25848206285004e-07 | ACTR3/ARPC1B/CALM2/CAP1/CORO1A/HCLS1/LCP1/TBC1D10C |
| NERF | 1.64933095087325e-05 | ACTR3/ARHGDIB/CALM2/CAP1/CORO1A/HCLS1/PTPN6 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_10_12 | GO:0030038 | contractile actin filament bundle assembly | 3/48 | 112/18986 | 0.00284950848743009 | 0.0400009273704789 | 0.0310429144123069 | PDLIM1/PFN1/RHOA | 3 |
| GO | B_10_12 | GO:0043149 | stress fiber assembly | 3/48 | 112/18986 | 0.00284950848743009 | 0.0400009273704789 | 0.0310429144123069 | PDLIM1/PFN1/RHOA | 3 |
| GO | B_10_12 | GO:0007596 | blood coagulation | 4/48 | 234/18986 | 0.00286125613627363 | 0.0400009273704789 | 0.0310429144123069 | ACTB/ILK/MYL12A/PTPN6 | 4 |
| KEGG | B_10_12 | hsa04022 | cGMP-PKG signaling pathway | 4/31 | 166/8541 | 0.00287523721718739 | 0.0145011963997277 | 0.0101324149072507 | CALM2/PPP1CA/RHOA/VASP | 4 |
| MeSH_gene2pubmed | B_10_12 | D015490 | HTLV-I Infections | 3/50 | 148/26076 | 0.00288866553376996 | 0.0326101187092104 | 0.0244790343397696 | ANXA6/PTPN6/RHOA | 3 |
| GO | B_10_12 | GO:0031941 | filamentous actin | 2/50 | 32/19960 | 0.00290731081217061 | 0.0155333463393116 | 0.00935585735044378 | ARPC3/PDLIM1 | 2 |
| reactome | B_10_12 | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2/43 | 21/11146 | 0.00291419189432345 | 0.025077388143257 | 0.0188897757138971 | MYL12A/RHOA | 2 |
| MeSH_gene2pubmed | B_10_12 | D020893 | Receptor, ErbB-3 | 3/50 | 149/26076 | 0.00294407210454767 | 0.0330454814816305 | 0.0248058427255765 | CSK/ILK/PTPN6 | 3 |
| GO | B_10_12 | GO:0002685 | regulation of leukocyte migration | 4/48 | 236/18986 | 0.00295011453412136 | 0.0408388404135231 | 0.0316931809083626 | CNN2/CORO1A/RAC2/RHOA | 4 |
| MeSH_gene2pubmed | B_10_12 | D020914 | Myopathies, Structural, Congenital | 2/50 | 42/26076 | 0.00295408611375811 | 0.0330454814816305 | 0.0248058427255765 | MTMR14/TPM3 | 2 |