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Selected Module: B_10_12


Module Info

Module_Name B_10_12
Cell_Type B
Name B_10_12: actin filament organization
Meta_Module B_13
Gene_Number 50

Genes:

ACTB, ACTR3, ANXA6, ARHGDIB, ARL6IP5, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, BBLN, CALM2, CAP1, CAPZB, CD53, CFL1, CNN2, CORO1A, CSK, DUS2, FDFT1, HCLS1, ILK, LCP1, MTMR14, MYL12A, MYO1G, PDLIM1, PFN1, PPP1CA, PPP1R18, PRR13, PTPN6, RAC2, RGS19, RHOA, RHOG, RPS6KA1, SHKBP1, SYTL1, TADA3, TBC1D10C, TBCB, TMSB4X, TPM3, TRAPPC1, TSC22D4, TWF2, UCP2, VASP


UMAP Visualizations


UMAP for B_10_12

UMAP for B_10_12


Word Cloud

Enriched TF

Wordcloud for B_10_12
TF p.adjust Genes
SRF 3.9374041695952e-11 ACTB/ACTR3/ANXA6/ARPC4/CAP1/CFL1/CNN2/LCP1/PFN1/TADA3/TPM3
SRF 3.9374041695952e-11 ACTB/ACTR3/ANXA6/ARPC4/CFL1/CNN2/LCP1/PFN1/TADA3/TPM3/VASP
SRF 5.15518863810196e-08 ACTR3/ANXA6/CAP1/CFL1/CNN2/PFN1
SRF 5.15654404051782e-08 ACTB/ACTR3/ANXA6/ARPC4/CFL1/CNN2/PFN1/TADA3/TPM3
ELK1 1.02349670677999e-07 ARHGDIB/ARPC4/LCP1/PPP1CA/SYTL1/TADA3/TBC1D10C/TRAPPC1/VASP
SRF 4.72727443461202e-07 ACTB/ANXA6/ARPC4/CFL1/PFN1/TADA3/TPM3/VASP
ETS 8.25848206285004e-07 ACTR3/ARPC1B/CALM2/CAP1/CORO1A/HCLS1/LCP1/TBC1D10C
NERF 1.64933095087325e-05 ACTR3/ARHGDIB/CALM2/CAP1/CORO1A/HCLS1/PTPN6


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
MeSH_gene2pubmed B_10_12 D013928 Thromboxane A2 3/50 113/26076 0.00133901938833802 0.0192235177597775 0.0144302802320022 HCLS1/RHOA/VASP 3
MeSH_gene2pubmed B_10_12 D011257 Pregnancy Proteins 5/50 428/26076 0.00134353720222744 0.0192235177597775 0.0144302802320022 ACTB/ANXA6/PFN1/PTPN6/RAC2 5
reactome B_10_12 R-HSA-447115 Interleukin-12 family signaling 3/43 57/11146 0.00135362371857244 0.0147544985324396 0.0111139631630158 CFL1/CNN2/LCP1 3
GO B_10_12 GO:0031258 lamellipodium membrane 2/50 22/19960 0.00137582312865836 0.00803996640809727 0.00484253535415934 CFL1/VASP 2
GO B_10_12 GO:0000910 cytokinesis 4/48 192/18986 0.00139322248923917 0.0256658447500681 0.0199181037608625 ACTR3/CALM2/CFL1/RHOA 4
GO B_10_12 GO:0043555 regulation of translation in response to stress 2/48 22/18986 0.00139986552528824 0.0256658447500681 0.0199181037608625 PPP1CA/RPS6KA1 2
GO B_10_12 GO:0050765 negative regulation of phagocytosis 2/48 22/18986 0.00139986552528824 0.0256658447500681 0.0199181037608625 CNN2/CSK 2
GO B_10_12 GO:1900242 regulation of synaptic vesicle endocytosis 2/48 22/18986 0.00139986552528824 0.0256658447500681 0.0199181037608625 ACTB/ARPC3 2
MeSH_gene2pubmed B_10_12 D009997 Osmotic Pressure 4/50 253/26076 0.0014040162554725 0.0199727399116637 0.0149926895549391 ACTR3/RHOA/TMSB4X/VASP 4
GO B_10_12 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 3/50 83/18737 0.00141379679945033 0.0281188474557344 0.019015980343484 MYO1G/PFN1/TWF2 3