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Selected Module: B_10_12


Module Info

Module_Name B_10_12
Cell_Type B
Name B_10_12: actin filament organization
Meta_Module B_13
Gene_Number 50

Genes:

ACTB, ACTR3, ANXA6, ARHGDIB, ARL6IP5, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, BBLN, CALM2, CAP1, CAPZB, CD53, CFL1, CNN2, CORO1A, CSK, DUS2, FDFT1, HCLS1, ILK, LCP1, MTMR14, MYL12A, MYO1G, PDLIM1, PFN1, PPP1CA, PPP1R18, PRR13, PTPN6, RAC2, RGS19, RHOA, RHOG, RPS6KA1, SHKBP1, SYTL1, TADA3, TBC1D10C, TBCB, TMSB4X, TPM3, TRAPPC1, TSC22D4, TWF2, UCP2, VASP


UMAP Visualizations


UMAP for B_10_12

UMAP for B_10_12


Word Cloud

Enriched TF

Wordcloud for B_10_12
TF p.adjust Genes
SRF 3.9374041695952e-11 ACTB/ACTR3/ANXA6/ARPC4/CAP1/CFL1/CNN2/LCP1/PFN1/TADA3/TPM3
SRF 3.9374041695952e-11 ACTB/ACTR3/ANXA6/ARPC4/CFL1/CNN2/LCP1/PFN1/TADA3/TPM3/VASP
SRF 5.15518863810196e-08 ACTR3/ANXA6/CAP1/CFL1/CNN2/PFN1
SRF 5.15654404051782e-08 ACTB/ACTR3/ANXA6/ARPC4/CFL1/CNN2/PFN1/TADA3/TPM3
ELK1 1.02349670677999e-07 ARHGDIB/ARPC4/LCP1/PPP1CA/SYTL1/TADA3/TBC1D10C/TRAPPC1/VASP
SRF 4.72727443461202e-07 ACTB/ANXA6/ARPC4/CFL1/PFN1/TADA3/TPM3/VASP
ETS 8.25848206285004e-07 ACTR3/ARPC1B/CALM2/CAP1/CORO1A/HCLS1/LCP1/TBC1D10C
NERF 1.64933095087325e-05 ACTR3/ARHGDIB/CALM2/CAP1/CORO1A/HCLS1/PTPN6


Functional Enrichment Results

enrichment_term
module ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
MeSH_gene2pubmed B_10_12 D030201 Activin Receptors, Type I 5/50 391/26076 0.00089942741326919 0.0141890440003556 0.0106511141045036 CNN2/PPP1CA/RAC2/RGS19/RHOA 5
GO B_10_12 GO:0031527 filopodium membrane 2/50 18/19960 0.00091711040229118 0.00591378086994658 0.0035619169889349 TBC1D10C/VASP 2
GO B_10_12 GO:0072678 T cell migration 3/48 76/18986 0.00093662011220769 0.0206641812255823 0.0160365384343456 CORO1A/MYO1G/RHOA 3
MeSH_gene2pubmed B_10_12 D024642 Potassium Channels, Voltage-Gated 5/50 402/26076 0.00101782713497824 0.0159546024151685 0.0119764439952184 CALM2/CSK/PPP1CA/PTPN6/RHOA 5
GO B_10_12 GO:1902905 positive regulation of supramolecular fiber organization 4/48 177/18986 0.00103169952839567 0.0224116882168413 0.0173926997418606 ARPC2/PFN1/RHOA/VASP 4
MeSH_gene2pubmed B_10_12 D051418 Focal Adhesion Kinase 2 4/50 233/26076 0.00103657720159222 0.0161055132733464 0.0120897263819684 CSK/ILK/PTPN6/RHOA 4
GO B_10_12 GO:0070064 proline-rich region binding 2/50 18/18737 0.00103900431932225 0.0232477216448353 0.0157217758844814 CSK/PFN1 2
GO B_10_12 GO:0098641 cadherin binding involved in cell-cell adhesion 2/50 18/18737 0.00103900431932225 0.0232477216448353 0.0157217758844814 PDLIM1/PPP1CA 2
MeSH_gene2pubmed B_10_12 D017830 Octoxynol 5/50 404/26076 0.00104054311680702 0.0161055132733464 0.0120897263819684 ACTB/ILK/PTPN6/RHOA/TMSB4X 5
MeSH_gene2pubmed B_10_12 D003931 Diacetyl 2/50 25/26076 0.0010509267529792 0.0161645671192614 0.0121340556018323 ACTB/PFN1 2