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Selected Module: B_10_11
Module Info
| Module_Name | B_10_11 |
| Cell_Type | B |
| Name | B_10_11: Eukaryotic Initiation Factors |
| Meta_Module | B_1 |
| Gene_Number | 41 |
Genes:
ABHD14B, APEX1, BTF3, C12orf57, CAMLG, CCNG1, CD48, COX4I1, EEF1D, EEF1G, EEF2, EIF3D, EIF3F, EIF4B, EPB41L4A-AS1, ESD, FAAP20, FAU, FXYD5, HSD17B11, PABPC1, PFDN5, PPDPF, RIC3, RPL15, RPL4, RPLP0, RPS2, RPS24, RPS3A, RSL1D1, SLC25A6, SMDT1, SMIM27, SNHG8, ST13, TOMM20, UXT, VPS51, ZFAS1, ZNF581
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| PSMB5 | 0.00080146689236252 | EEF2/FAU/PABPC1/RPLP0/RPS2/ZFAS1 |
| MYBL1 | 0.00080146689236252 | COX4I1/FXYD5/PFDN5/RPL15/RPLP0/SMIM27/SNHG8 |
| ZZZ3 | 0.00870215838282488 | EIF3F/RPL15/RPS2/RPS3A/VPS51 |
| RAX2 | 0.00900930942131189 | EEF1G/RPL4/ZNF581 |
| NPM1 | 0.00900930942131189 | COX4I1/EEF2/PFDN5/RPS3A/SNHG8 |
| SETBP1 | 0.00900930942131189 | COX4I1/EEF1G/EIF3D/EIF4B |
| TBX1 | 0.016994876277699 | EIF3F/PFDN5/RPS3A/ZFAS1 |
| HOXA10 | 0.0235563762951255 | EEF1G/EPB41L4A-AS1/FAU/RPL4 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_10_11 | GO:0045182 | translation regulator activity | 7/36 | 438/18737 | 1.68818343707935e-05 | 0.00037421399521925 | 0.00027840218085168 | EEF1D/EEF1G/EEF2/EIF3D/EIF3F/EIF4B/PABPC1 | 7 |
| hallmark | B_10_11 | HALLMARK_MYC_TARGETS_V1 | HALLMARK_MYC_TARGETS_V1 | 6/14 | 200/4384 | 1.84882189229217e-05 | 0.00022185862707506 | 0.00019461283076759 | APEX1/EIF3D/PABPC1/RPLP0/RPS2/RSL1D1 | 6 |
| reactome | B_10_11 | R-HSA-71291 | Metabolism of amino acids and derivatives | 7/30 | 367/11146 | 4.18909640990862e-05 | 0.00015185474485918 | 9.23254800868017e-05 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 7 |
| MeSH_gene2pubmed | B_10_11 | D039562 | Eukaryotic Initiation Factor-4F | 3/39 | 45/26076 | 4.20219038091732e-05 | 0.00326930411635367 | 0.00279261353735347 | BTF3/EIF4B/PABPC1 | 3 |
| GO | B_10_11 | GO:0006413 | translational initiation | 4/37 | 127/18986 | 0.00010628526039926 | 0.0213101947100529 | 0.0185719507645034 | EIF3D/EIF3F/EIF4B/RPS3A | 4 |
| reactome | B_10_11 | R-HSA-9692914 | SARS-CoV-1-host interactions | 4/30 | 96/11146 | 0.00011927535998979 | 0.00041927096238835 | 0.00025491065771343 | FAU/RPS2/RPS24/RPS3A | 4 |
| MeSH_gene2pubmed | B_10_11 | D010454 | Peptide Termination Factors | 3/39 | 65/26076 | 0.00012670527767679 | 0.00924156619055117 | 0.00789407223420553 | EIF3F/PABPC1/RPL4 | 3 |
| GO | B_10_11 | GO:0003743 | translation initiation factor activity | 3/36 | 51/18737 | 0.00012731369735093 | 0.00241896024966768 | 0.00179962218811842 | EIF3D/EIF3F/EIF4B | 3 |
| MeSH_gene2pubmed | B_10_11 | D019893 | Ribosomal Protein S6 Kinases | 5/39 | 341/26076 | 0.00014841972280984 | 0.0101885774422993 | 0.00870300170284351 | EEF1D/EEF2/EIF3F/EIF4B/RPL4 | 5 |
| MeSH_gene2pubmed | B_10_11 | D014637 | Valine-tRNA Ligase | 2/39 | 13/26076 | 0.00016825114073874 | 0.0109082822912283 | 0.00931776785260739 | EEF1D/EEF1G | 2 |