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Selected Module: B_10_11
Module Info
| Module_Name | B_10_11 |
| Cell_Type | B |
| Name | B_10_11: Eukaryotic Initiation Factors |
| Meta_Module | B_1 |
| Gene_Number | 41 |
Genes:
ABHD14B, APEX1, BTF3, C12orf57, CAMLG, CCNG1, CD48, COX4I1, EEF1D, EEF1G, EEF2, EIF3D, EIF3F, EIF4B, EPB41L4A-AS1, ESD, FAAP20, FAU, FXYD5, HSD17B11, PABPC1, PFDN5, PPDPF, RIC3, RPL15, RPL4, RPLP0, RPS2, RPS24, RPS3A, RSL1D1, SLC25A6, SMDT1, SMIM27, SNHG8, ST13, TOMM20, UXT, VPS51, ZFAS1, ZNF581
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| PSMB5 | 0.00080146689236252 | EEF2/FAU/PABPC1/RPLP0/RPS2/ZFAS1 |
| MYBL1 | 0.00080146689236252 | COX4I1/FXYD5/PFDN5/RPL15/RPLP0/SMIM27/SNHG8 |
| ZZZ3 | 0.00870215838282488 | EIF3F/RPL15/RPS2/RPS3A/VPS51 |
| RAX2 | 0.00900930942131189 | EEF1G/RPL4/ZNF581 |
| NPM1 | 0.00900930942131189 | COX4I1/EEF2/PFDN5/RPS3A/SNHG8 |
| SETBP1 | 0.00900930942131189 | COX4I1/EEF1G/EIF3D/EIF4B |
| TBX1 | 0.016994876277699 | EIF3F/PFDN5/RPS3A/ZFAS1 |
| HOXA10 | 0.0235563762951255 | EEF1G/EPB41L4A-AS1/FAU/RPL4 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| reactome | B_10_11 | R-HSA-72764 | Eukaryotic Translation Termination | 7/30 | 94/11146 | 4.20532977478365e-09 | 2.71010141041613e-08 | 1.64770230941815e-08 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 7 |
| MeSH_gene2pubmed | B_10_11 | D005815 | Genetic Code | 8/39 | 262/26076 | 4.38682710652652e-09 | 6.39928404164556e-07 | 5.46621746036922e-07 | CD48/FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 8 |
| reactome | B_10_11 | R-HSA-168255 | Influenza Infection | 8/30 | 157/11146 | 5.8315420532206e-09 | 3.56030988512415e-08 | 2.16461671781596e-08 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A/SLC25A6 | 8 |
| reactome | B_10_11 | R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7/30 | 102/11146 | 7.47754352071959e-09 | 4.33697524201736e-08 | 2.63681797835902e-08 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 7 |
| GO | B_10_11 | GO:0008135 | translation factor activity, RNA binding | 6/36 | 83/18737 | 1.10130577440805e-08 | 7.32368339981356e-07 | 5.44856541022932e-07 | EEF1D/EEF1G/EEF2/EIF3D/EIF3F/EIF4B | 6 |
| reactome | B_10_11 | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8/30 | 172/11146 | 1.19737186624474e-08 | 6.61405411830428e-08 | 4.02124887410515e-08 | FAU/PABPC1/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 8 |
| reactome | B_10_11 | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7/30 | 113/11146 | 1.53283935156648e-08 | 8.08224385371416e-08 | 4.91388691650498e-08 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 7 |
| reactome | B_10_11 | R-HSA-2408522 | Selenoamino acid metabolism | 7/30 | 119/11146 | 2.19920854797955e-08 | 1.10916605028534e-07 | 6.74356854529198e-08 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 7 |
| MeSH_gene2pubmed | B_10_11 | D018075 | RNA, Complementary | 8/39 | 325/26076 | 2.34883342043007e-08 | 3.04565400182433e-06 | 2.60157339081553e-06 | EIF3D/EIF3F/EIF4B/FAU/PABPC1/RPS2/RPS24/RPS3A | 8 |
| GO | B_10_11 | GO:0003735 | structural constituent of ribosome | 7/36 | 175/18737 | 3.65191566308248e-08 | 1.61901594396656e-06 | 1.20449148185878e-06 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 7 |