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Selected Module: B_10_11
Module Info
| Module_Name | B_10_11 |
| Cell_Type | B |
| Name | B_10_11: Eukaryotic Initiation Factors |
| Meta_Module | B_1 |
| Gene_Number | 41 |
Genes:
ABHD14B, APEX1, BTF3, C12orf57, CAMLG, CCNG1, CD48, COX4I1, EEF1D, EEF1G, EEF2, EIF3D, EIF3F, EIF4B, EPB41L4A-AS1, ESD, FAAP20, FAU, FXYD5, HSD17B11, PABPC1, PFDN5, PPDPF, RIC3, RPL15, RPL4, RPLP0, RPS2, RPS24, RPS3A, RSL1D1, SLC25A6, SMDT1, SMIM27, SNHG8, ST13, TOMM20, UXT, VPS51, ZFAS1, ZNF581
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| PSMB5 | 0.00080146689236252 | EEF2/FAU/PABPC1/RPLP0/RPS2/ZFAS1 |
| MYBL1 | 0.00080146689236252 | COX4I1/FXYD5/PFDN5/RPL15/RPLP0/SMIM27/SNHG8 |
| ZZZ3 | 0.00870215838282488 | EIF3F/RPL15/RPS2/RPS3A/VPS51 |
| RAX2 | 0.00900930942131189 | EEF1G/RPL4/ZNF581 |
| NPM1 | 0.00900930942131189 | COX4I1/EEF2/PFDN5/RPS3A/SNHG8 |
| SETBP1 | 0.00900930942131189 | COX4I1/EEF1G/EIF3D/EIF4B |
| TBX1 | 0.016994876277699 | EIF3F/PFDN5/RPS3A/ZFAS1 |
| HOXA10 | 0.0235563762951255 | EEF1G/EPB41L4A-AS1/FAU/RPL4 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| MeSH_gene2pubmed | B_10_11 | D015138 | RNA, Nuclear | 7/39 | 108/26076 | 2.36723403206124e-10 | 3.94651730773637e-08 | 3.37108365167217e-08 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 7 |
| reactome | B_10_11 | R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8/30 | 116/11146 | 5.2158886284142e-10 | 4.32173629211463e-09 | 2.62755291807332e-09 | FAU/PABPC1/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 8 |
| reactome | B_10_11 | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8/30 | 116/11146 | 5.2158886284142e-10 | 4.32173629211463e-09 | 2.62755291807332e-09 | FAU/PABPC1/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 8 |
| GO | B_10_11 | GO:0005840 | ribosome | 9/39 | 245/19960 | 8.39676739226058e-10 | 7.64105832695713e-08 | 5.74515663680987e-08 | APEX1/EEF2/FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 9 |
| GO | B_10_11 | GO:0090079 | translation regulator activity, nucleic acid binding | 7/36 | 110/18737 | 1.43742221332613e-09 | 1.91177154372375e-07 | 1.42229145318586e-07 | EEF1D/EEF1G/EEF2/EIF3D/EIF3F/EIF4B/PABPC1 | 7 |
| WikiPathways | B_10_11 | WP477 | Cytoplasmic ribosomal proteins | 7/24 | 88/8836 | 2.30169128003428e-09 | 4.02795974005999e-08 | 3.63424938952781e-08 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 7 |
| GO | B_10_11 | GO:0022626 | cytosolic ribosome | 7/39 | 118/19960 | 2.77308545871308e-09 | 1.26175388371445e-07 | 9.4868713061237e-08 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 7 |
| reactome | B_10_11 | R-HSA-192823 | Viral mRNA Translation | 7/30 | 90/11146 | 3.09193848098446e-09 | 2.39109909196132e-08 | 1.45375353141024e-08 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 7 |
| reactome | B_10_11 | R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 6/30 | 52/11146 | 4.17457918049367e-09 | 2.71010141041613e-08 | 1.64770230941815e-08 | EIF3D/EIF3F/FAU/RPS2/RPS24/RPS3A | 6 |
| reactome | B_10_11 | R-HSA-2408557 | Selenocysteine synthesis | 7/30 | 94/11146 | 4.20532977478365e-09 | 2.71010141041613e-08 | 1.64770230941815e-08 | FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 7 |