Module Explorer
Instructions
- Enter a module name.
- Click Submit to search for the detailed information of the module.
- Results will appear below if available.
Selected Module: B_10_11
Module Info
| Module_Name | B_10_11 |
| Cell_Type | B |
| Name | B_10_11: Eukaryotic Initiation Factors |
| Meta_Module | B_1 |
| Gene_Number | 41 |
Genes:
ABHD14B, APEX1, BTF3, C12orf57, CAMLG, CCNG1, CD48, COX4I1, EEF1D, EEF1G, EEF2, EIF3D, EIF3F, EIF4B, EPB41L4A-AS1, ESD, FAAP20, FAU, FXYD5, HSD17B11, PABPC1, PFDN5, PPDPF, RIC3, RPL15, RPL4, RPLP0, RPS2, RPS24, RPS3A, RSL1D1, SLC25A6, SMDT1, SMIM27, SNHG8, ST13, TOMM20, UXT, VPS51, ZFAS1, ZNF581
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| PSMB5 | 0.00080146689236252 | EEF2/FAU/PABPC1/RPLP0/RPS2/ZFAS1 |
| MYBL1 | 0.00080146689236252 | COX4I1/FXYD5/PFDN5/RPL15/RPLP0/SMIM27/SNHG8 |
| ZZZ3 | 0.00870215838282488 | EIF3F/RPL15/RPS2/RPS3A/VPS51 |
| RAX2 | 0.00900930942131189 | EEF1G/RPL4/ZNF581 |
| NPM1 | 0.00900930942131189 | COX4I1/EEF2/PFDN5/RPS3A/SNHG8 |
| SETBP1 | 0.00900930942131189 | COX4I1/EEF1G/EIF3D/EIF4B |
| TBX1 | 0.016994876277699 | EIF3F/PFDN5/RPS3A/ZFAS1 |
| HOXA10 | 0.0235563762951255 | EEF1G/EPB41L4A-AS1/FAU/RPL4 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| MeSH_gene2pubmed | B_10_11 | D018387 | Codon, Initiator | 12/39 | 353/26076 | 8.85667981226936e-14 | 1.87702648272969e-11 | 1.60334107170434e-11 | EEF1D/EEF1G/EEF2/EIF3D/FAU/PABPC1/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 12 |
| MeSH_gene2pubmed | B_10_11 | D019843 | Archaeal Proteins | 10/39 | 179/26076 | 9.6505217621064e-14 | 1.87702648272969e-11 | 1.60334107170434e-11 | EEF1D/EEF1G/EEF2/FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 10 |
| reactome | B_10_11 | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 10/30 | 113/11146 | 1.93981074428514e-13 | 3.75030077228461e-12 | 2.28012841872113e-12 | EIF3D/EIF3F/EIF4B/FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 10 |
| reactome | B_10_11 | R-HSA-72649 | Translation initiation complex formation | 8/30 | 59/11146 | 2.01331100768652e-12 | 3.33634395559481e-11 | 2.02844868443605e-11 | EIF3D/EIF3F/EIF4B/FAU/PABPC1/RPS2/RPS24/RPS3A | 8 |
| reactome | B_10_11 | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 8/30 | 60/11146 | 2.31896024470643e-12 | 3.36249235482433e-11 | 2.04434653151751e-11 | EIF3D/EIF3F/EIF4B/FAU/PABPC1/RPS2/RPS24/RPS3A | 8 |
| reactome | B_10_11 | R-HSA-72689 | Formation of a pool of free 40S subunits | 9/30 | 102/11146 | 3.83493094812162e-12 | 4.94279988869009e-11 | 3.0051505675339e-11 | EIF3D/EIF3F/FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 9 |
| WikiPathways | B_10_11 | WP107 | Translation factors | 7/24 | 52/8836 | 5.1555856947301e-11 | 1.80445499315553e-09 | 1.62807969307266e-09 | EEF1D/EEF1G/EEF2/EIF3D/EIF3F/EIF4B/PABPC1 | 7 |
| reactome | B_10_11 | R-HSA-156902 | Peptide chain elongation | 8/30 | 90/11146 | 6.66332618518943e-11 | 7.72945837481974e-10 | 4.69939846744939e-10 | EEF2/FAU/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 8 |
| reactome | B_10_11 | R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 8/30 | 96/11146 | 1.1278398255097e-10 | 1.1893583614466e-09 | 7.23112615398566e-10 | FAU/PABPC1/RPL15/RPL4/RPLP0/RPS2/RPS24/RPS3A | 8 |
| reactome | B_10_11 | R-HSA-72702 | Ribosomal scanning and start codon recognition | 7/30 | 59/11146 | 1.49349532348537e-10 | 1.44371214603586e-09 | 8.7775602345193e-10 | EIF3D/EIF3F/EIF4B/FAU/RPS2/RPS24/RPS3A | 7 |