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Selected Module: B_10_11
Module Info
| Module_Name | B_10_11 |
| Cell_Type | B |
| Name | B_10_11: Eukaryotic Initiation Factors |
| Meta_Module | B_1 |
| Gene_Number | 41 |
Genes:
ABHD14B, APEX1, BTF3, C12orf57, CAMLG, CCNG1, CD48, COX4I1, EEF1D, EEF1G, EEF2, EIF3D, EIF3F, EIF4B, EPB41L4A-AS1, ESD, FAAP20, FAU, FXYD5, HSD17B11, PABPC1, PFDN5, PPDPF, RIC3, RPL15, RPL4, RPLP0, RPS2, RPS24, RPS3A, RSL1D1, SLC25A6, SMDT1, SMIM27, SNHG8, ST13, TOMM20, UXT, VPS51, ZFAS1, ZNF581
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| PSMB5 | 0.00080146689236252 | EEF2/FAU/PABPC1/RPLP0/RPS2/ZFAS1 |
| MYBL1 | 0.00080146689236252 | COX4I1/FXYD5/PFDN5/RPL15/RPLP0/SMIM27/SNHG8 |
| ZZZ3 | 0.00870215838282488 | EIF3F/RPL15/RPS2/RPS3A/VPS51 |
| RAX2 | 0.00900930942131189 | EEF1G/RPL4/ZNF581 |
| NPM1 | 0.00900930942131189 | COX4I1/EEF2/PFDN5/RPS3A/SNHG8 |
| SETBP1 | 0.00900930942131189 | COX4I1/EEF1G/EIF3D/EIF4B |
| TBX1 | 0.016994876277699 | EIF3F/PFDN5/RPS3A/ZFAS1 |
| HOXA10 | 0.0235563762951255 | EEF1G/EPB41L4A-AS1/FAU/RPL4 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| GO | B_10_11 | GO:0048027 | mRNA 5'-UTR binding | 2/36 | 24/18737 | 0.00096460549667866 | 0.0160365663822828 | 0.0119306469326045 | RPS3A/RSL1D1 | 2 |
| WikiPathways | B_10_11 | WP5027 | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell | 2/24 | 18/8836 | 0.00105349569851674 | 0.0122907831493619 | 0.0110894284054393 | EIF3D/EIF3F | 2 |
| reactome | B_10_11 | R-HSA-8876725 | Protein methylation | 2/30 | 19/11146 | 0.00116400064631786 | 0.00375066874924644 | 0.00228035214337125 | EEF2/RPS2 | 2 |
| MeSH_gene2pubmed | B_10_11 | D007935 | Leucine-tRNA Ligase | 2/39 | 34/26076 | 0.00118634387204252 | 0.0477401137473662 | 0.0407792249301004 | EEF1D/EEF1G | 2 |
| MeSH_gene2pubmed | B_10_11 | D010850 | Picornaviridae Infections | 2/39 | 35/26076 | 0.00125705660556538 | 0.0488995019564933 | 0.0417695651042251 | EIF4B/PABPC1 | 2 |
| GO | B_10_11 | GO:0005925 | focal adhesion | 5/39 | 424/19960 | 0.00134170949272382 | 0.0104099064097058 | 0.0078269973005307 | PABPC1/RPL4/RPLP0/RPS2/RPS3A | 5 |
| GO | B_10_11 | GO:0015934 | large ribosomal subunit | 3/39 | 114/19960 | 0.00142759905287591 | 0.0104099064097058 | 0.0078269973005307 | RPL15/RPL4/RPLP0 | 3 |
| GO | B_10_11 | GO:0030055 | cell-substrate junction | 5/39 | 434/19960 | 0.00148712948710083 | 0.0104099064097058 | 0.0078269973005307 | PABPC1/RPL4/RPLP0/RPS2/RPS3A | 5 |
| GO | B_10_11 | GO:0031369 | translation initiation factor binding | 2/36 | 32/18737 | 0.00171683416586402 | 0.0253709937844349 | 0.018875135858622 | EIF3F/RPS24 | 2 |
| reactome | B_10_11 | R-HSA-429947 | Deadenylation of mRNA | 2/30 | 24/11146 | 0.00186309834420932 | 0.00568735284021793 | 0.00345782795185664 | EIF4B/PABPC1 | 2 |