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Selected Module: B_10_10
Module Info
| Module_Name | B_10_10 |
| Cell_Type | B |
| Name | B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB |
| Meta_Module | B_12 |
| Gene_Number | 41 |
Genes:
ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| ATF1 | 2.40623980358193e-06 | AREG/CHMP1B/DDIT3/FOS/FOSB/JUND/TSC22D3 |
| SRF | 2.86827702005306e-06 | DUSP2/FOS/FOSB/JUNB/KLF6/MYADM/NR4A1 |
| ATF3 | 2.98759212708808e-06 | AREG/DUSP1/EIF1/FOSB/JUN/JUND/PPP1R15A |
| ATF4 | 3.38509215897492e-06 | DUSP1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| ATF | 3.47336957893601e-06 | DUSP1/EIF1/FOS/FOSB/JUND/NR4A2/PPP1R15A |
| CREB | 3.47336957893601e-06 | AREG/CHMP1B/DUSP1/FOSB/JUND/NR4A2/PPP1R15A |
| E4F1 | 5.79673683758279e-06 | DUSP1/EIF1/FOSB/NR4A1/NR4A2/PPP1R15A/TSC22D3 |
| SRF | 2.29027353471601e-05 | FOS/FOSB/IER2/JUNB/KLF6/MYADM |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| hallmark | B_10_10 | HALLMARK_TNFA_SIGNALING_VIA_NFKB | HALLMARK_TNFA_SIGNALING_VIA_NFKB | 21/28 | 200/4384 | 2.20095918552487e-23 | 5.50239796381217e-22 | 3.47519871398663e-22 | AREG/BTG2/CCNL1/CD69/CD83/DUSP1/DUSP2/EIF1/FOS/FOSB/GADD45B/IER2/JUN/JUNB/KLF6/NFKBIA/NR4A1/NR4A2/PPP1R15A/SLC2A3/ZFP36 | 21 |
| MeSH_gene2pubmed | B_10_10 | D017781 | Genes, Immediate-Early | 13/41 | 272/26076 | 1.76345692359856e-16 | 5.17750952768537e-13 | 3.21691668273295e-13 | BTG2/CCNL1/DUSP1/DUSP2/FOS/FOSB/GADD45B/IFRD1/JUN/JUNB/NR4A2/PPP1R15A/ZFP36 | 13 |
| MeSH_gene2pubmed | B_10_10 | D051766 | Early Growth Response Protein 1 | 12/41 | 353/26076 | 1.7458883924283e-13 | 2.56296416008474e-10 | 1.59243399162013e-10 | AREG/CD69/DDIT3/DUSP1/FOS/FOSB/GADD45B/IFRD1/JUN/JUNB/PPP1R15A/ZFP36 | 12 |
| MeSH_gene2pubmed | B_10_10 | D051700 | Activating Transcription Factor 3 | 8/41 | 101/26076 | 3.28338302819663e-12 | 3.2133375235951e-09 | 1.99652729398763e-09 | DDIT3/FOS/FOSB/GADD45B/JUN/JUNB/JUND/KLF6 | 8 |
| MeSH_gene2pubmed | B_10_10 | D016758 | Genes, jun | 9/41 | 250/26076 | 1.58889679739047e-10 | 1.16625024928461e-07 | 7.24620565757286e-08 | DDIT3/FOS/FOSB/IFRD1/JUN/JUNB/JUND/TSC22D3/ZNF331 | 9 |
| MeSH_gene2pubmed | B_10_10 | D051900 | Smad3 Protein | 10/41 | 421/26076 | 7.76087927252018e-10 | 4.55718830882385e-07 | 2.83149553247947e-07 | DDIT3/DUSP1/FOS/FOSB/GADD45B/JUN/JUNB/JUND/NFKBIA/ZFP36 | 10 |
| MeSH_gene2pubmed | B_10_10 | D016762 | Genes, fos | 10/41 | 432/26076 | 9.95184466768573e-10 | 4.86976932405422e-07 | 3.02570996650866e-07 | AREG/DDIT3/FOS/FOSB/GADD45B/IFRD1/JUN/JUNB/TSC22D3/ZFP36 | 10 |
| MeSH_gene2pubmed | B_10_10 | D051790 | G-Box Binding Factors | 6/41 | 70/26076 | 1.25499834914226e-09 | 5.26382164725955e-07 | 3.27054457002036e-07 | DDIT3/DUSP1/FOS/JUN/JUND/KLF6 | 6 |
| MeSH_gene2pubmed | B_10_10 | D051776 | Early Growth Response Protein 3 | 5/41 | 35/26076 | 2.3401617154497e-09 | 8.58839349570041e-07 | 5.3361845432557e-07 | FOS/JUN/NR4A1/NR4A2/TSC22D3 | 5 |
| MeSH_gene2pubmed | B_10_10 | D050687 | E2F1 Transcription Factor | 9/41 | 370/26076 | 4.96718264751231e-09 | 1.62040536145513e-06 | 1.00679854130279e-06 | CXCR4/DUSP1/DUSP2/FOS/JUN/KLF6/NR4A1/PMAIP1/SERTAD1 | 9 |