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Selected Module: B_10_10
Module Info
| Module_Name | B_10_10 |
| Cell_Type | B |
| Name | B_10_10: HALLMARK_TNFA_SIGNALING_VIA_NFKB |
| Meta_Module | B_12 |
| Gene_Number | 41 |
Genes:
ALG13, AREG, BTG2, CCNL1, CD69, CD83, CHMP1B, COQ7, CSRNP1, CXCR4, DDIT3, DUSP1, DUSP2, EIF1, FOS, FOSB, GADD45B, IER2, IFRD1, JUN, JUNB, JUND, KLF6, LY9, MYADM, NFKBIA, NFKBID, NR4A1, NR4A2, PHACTR1, PMAIP1, PPP1R15A, RBM38, SBDS, SERTAD1, SLC2A3, TSC22D3, TUBA1A, YPEL5, ZFP36, ZNF331
UMAP Visualizations
Word Cloud
Enriched TF
| TF | p.adjust | Genes |
|---|---|---|
| PSMB5 | 4.90379990902434e-09 | BTG2/CCNL1/DUSP1/EIF1/JUNB/PMAIP1/PPP1R15A/SLC2A3/TUBA1A/ZFP36 |
| CREB | 4.90379990902434e-09 | AREG/CHMP1B/DUSP1/EIF1/FOSB/JUND/NR4A2/PPP1R15A/TSC22D3 |
| CREB | 4.90379990902434e-09 | AREG/DUSP1/FOSB/JUN/JUND/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| CREB | 1.73096420202783e-08 | DUSP1/EIF1/FOS/FOSB/GADD45B/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| SRF | 1.17134429958281e-07 | DUSP2/FOS/FOSB/IER2/IFRD1/JUNB/KLF6/NR4A1 |
| CREB | 3.64129821560901e-07 | DUSP1/EIF1/FOS/FOSB/NFKBID/NR4A2/PPP1R15A/TSC22D3 |
| ATF | 6.82227196758743e-07 | AREG/CHMP1B/DUSP1/FOS/FOSB/JUND/PPP1R15A |
| SRF | 1.34911861648055e-06 | DUSP2/FOS/FOSB/IER2/JUNB/KLF6/NR4A1 |
Functional Enrichment Results
|
enrichment_term
|
module | ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count |
|---|---|---|---|---|---|---|---|---|---|---|
| MeSH_gene2pubmed | B_10_10 | D008050 | D008050 | 2/41 | 57/26076 | 0.00364454591435906 | 0.0262264382464662 | 0.0162951446583701 | CD83/DUSP1 | 2 |
| MeSH_gene2pubmed | B_10_10 | D051269 | Sodium-Glucose Transporter 1 | 2/41 | 57/26076 | 0.00364454591435906 | 0.0262264382464662 | 0.0162951446583701 | SLC2A3/TUBA1A | 2 |
| WikiPathways | B_10_10 | WP3613 | Photodynamic therapy induced unfolded protein response | 2/30 | 27/8836 | 0.00371063095939169 | 0.0199803205505707 | 0.0124188458559938 | DDIT3/PPP1R15A | 2 |
| reactome | B_10_10 | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3/24 | 147/11146 | 0.00371287729121261 | 0.0313039832866607 | 0.0217453623512708 | FOS/JUN/NFKBIA | 3 |
| MeSH_gene2pubmed | B_10_10 | D020890 | Neuregulin-1 | 3/41 | 198/26076 | 0.00371746077343045 | 0.0266857330826205 | 0.0165805160734911 | AREG/DDIT3/JUN | 3 |
| MeSH_gene2pubmed | B_10_10 | D015843 | Serpins | 4/41 | 407/26076 | 0.00375377231712534 | 0.0268152689126034 | 0.0166609999374522 | DDIT3/DUSP1/NR4A1/PPP1R15A | 4 |
| MeSH_gene2pubmed | B_10_10 | D051197 | Toll-Like Receptor 4 | 4/41 | 407/26076 | 0.00375377231712534 | 0.0268152689126034 | 0.0166609999374522 | CD83/CXCR4/DUSP1/NFKBIA | 4 |
| MeSH_gene2pubmed | B_10_10 | D054713 | Bryostatins | 2/41 | 58/26076 | 0.0037709643760739 | 0.0268726975926043 | 0.0166966818184365 | AREG/FOSB | 2 |
| reactome | B_10_10 | R-HSA-5675221 | Negative regulation of MAPK pathway | 2/24 | 43/11146 | 0.00380210323319766 | 0.0313039832866607 | 0.0217453623512708 | DUSP1/DUSP2 | 2 |
| MeSH_gene2pubmed | B_10_10 | D009685 | Nuclear Envelope | 4/41 | 409/26076 | 0.00381975850698805 | 0.027154505996409 | 0.0168717764562515 | AREG/FOS/JUN/MYADM | 4 |